| Product Number |
OAAN00882 |
| Product Page |
www.avivasysbio.com/cyp3a4-antibody-oaan00882.html |
| Name |
CYP3A4 Antibody (OAAN00882) |
| Molecular Weight |
57 kD |
| Isotype |
IgG |
| Conjugation |
Unconjugated |
| NCBI Gene Id |
1576 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Gene Full Name |
cytochrome P450 family 3 subfamily A member 4 |
| Alias Symbols |
HLP, CP33, CP34, CYP3A, NF-25, VDDR3, CYP3A3, P450C3, CYPIIIA3, CYPIIIA4, P450PCN1 |
| Product Format |
Liquid |
| Description of Target |
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified. |
| Reconstitution and Storage |
Store at -20C. Avoid repeated freeze/thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-CYP3A4 (OAAN00882) |
| Application Info |
WB: 1:500 - 1:2,000. IHC: 1:50 - 1:200. FC: 1:20 - 1:100 |
| Immunogen |
A synthetic Peptide of human CYP3A4 |
| Storage Buffer |
PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Uniprot ID |
P08684 |
| Protein Name |
Cytochrome P450 3A4 |
| Protein Accession # |
NP_001189784.1 |
| Purification |
Affinity purified against immunogen |
| Nucleotide Accession # |
NM_001202855.2 |
| Preservative |
0.02% Sodium Azide |
| Gene Symbol |
CYP3A4 |
| Predicted Species Reactivity |
Human, Mouse, Rat |
| Application |
WB, IHC, FC |
| Image 1 | Multiple Cell Lines
 | Western blot analysis of extracts of various cell lines, using CYP3A4 antibody. |
| | Image 2 | Human Liver,Multiple Cell Lines
 | Immunohistochemistry of paraffin-embedded human liver cancer using CYP3A4 antibody at dilution of 1:100 (400x lens). |
|
|
