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CYP3A4 Antibody (OAAN00882)

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Gene Symbol:
CYP3A4
Official Gene Full Name:
cytochrome P450 family 3 subfamily A member 4
NCBI Gene Id:
1576
Protein Name:
Cytochrome P450 3A4
Swissprot Id:
P08684
Protein Accession #:
NP_001189784.1
Nucleotide Accession #:
NM_001202855.2
Alias Symbols:
CP33, CP34, CYP3A, CYP3A3, HLP, MGC126680, NF-25, P450C3, P450PCN1, HLP, CP33, CP34, CYP3A, NF-25, CYP3A3, P450C3, CYPIIIA3, CYPIIIA4, P450PCN1, cytochrome P450 family 3 subfamily A member 4, Cytochrome P450 3A4, CYP3A4
Description of Target:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified.
Molecular Weight:
57 kD
Host:
Rabbit
Clonality:
Polyclonal
Purification:
Affinity purified against immunogen
Application:
WB, IHC, FC
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express CYP3A4.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express CYP3A4.
Immunogen:
A synthetic Peptide of human CYP3A4
Predicted Species Reactivity:
Human, Mouse, Rat
Product Format:
Liquid
Reconstitution and Storage:
Store at -20C. Avoid repeated freeze/thaw cycles.
Datasheets/Manuals:
Printable datasheet for anti-CYP3A4 (OAAN00882)
Preservative:
0.02% Sodium Azide
Conjugation:
Unconjugated
Isotype:
IgG
Application Info:
WB: 1:500 - 1:2,000. IHC: 1:50 - 1:200. FC: 1:20 - 1:100
Storage Buffer:
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

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