| Product Number |
OAAI00228 |
| Product Page |
www.avivasysbio.com/anti-erk2-antibody-ct-polyclonal-antibody-oaai00228.html |
| Name |
Anti-ERK2 Antibody (CT) Polyclonal Antibody (OAAI00228) |
| Molecular Weight |
42 |
| Isotype |
Rabbit IgG |
| NCBI Gene Id |
5594 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
100ug/200ul |
| Gene Full Name |
mitogen-activated protein kinase 1 |
| Alias Symbols |
ERK;ERK2;ERK-2;ERT1;extracellular signal-regulated kinase 2;MAP kinase 1;MAP kinase 2;MAPK 2;MAPK2;mitogen-activated protein kinase 1;mitogen-activated protein kinase 2;NS13;p38;p40;p41;p41mapk;p42-MAPK;P42MAPK;PRKM1;PRKM2;protein tyrosine kinase ERK2. |
| Product Format |
Liquid. This affinity purified antibody is supplied in sterile Phosphatebuffered saline (pH7.2) containing antibody stabilizer |
| Reference |
M. Klink, et al. Ovarian Cancer Cells Modulate Human Blood Neutrophils Response to Activation In Vitro. Clinical Immunology, 68 (3), 328-336. 2008. |
| Description of Target |
The extracellular signal-regulated kinases ½ (ERK1/2) are known as MAPK (Mitogen-activated protein kinases) are a widely conserved family of serine/threonine protein kinases involved in many cellular programs such as cell prolifeRation, differentiation, motility, and death. ERK2 is also known as mitogen activated protein kinase 2, microtubule-associated protein-2 kinase, MAP kinse 2, p42-MAPK or EGF receptor T669 (ERT1). The p44/42 MAPK (ERK1/2) signaling pathway can be activated in response to a diverse range of extracellular stimuli including mitogens, growth factors, and cytokines and is an important target in the diagnosis and treatment of cancer. The phosphorylation of MAPK at Thr202 and Tyr 204 are correlated to the progression and metastatic potential of tumor cells. |
| Reconstitution and Storage |
The antibodies are stable for 24 months from date of receipt when stored at -20C to -70C. The antibodies can be stored at 2C-8C for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles. |
| Datasheets/Manuals |
Printable datasheet for Anti-ERK2 Antibody (CT) Polyclonal Antibody (OAAI00228) |
| Specificity |
MAPK1 |
| Additional Information |
Background: The extracellular signal-regulated kinases ½ (ERK1/2) are known as MAPK (Mitogen-activated protein kinases) are a widely conserved family of serine/threonine protein kinases involved in many cellular programs such as cell proliferation, differentiation, motility, and death. ERK2 is also known as mitogen activated protein kinase 2, microtubule-associated protein-2 kinase, MAP kinse 2, p42-MAPK or EGF receptor T669 (ERT1). The p44/42 MAPK (ERK1/2) signaling pathway can be activated in response to a diverse range of extracellular stimuli including mitogens, growth factors, and cytokines and is an important target in the diagnosis and treatment of cancer. The phosphorylation of MAPK at Thr202 and Tyr 204 are correlated to the progression and metastatic potential of tumor cells. |
| Additional Information |
Positive Control: A431 cells |
| Application Info |
WB: 0.1-1 ug/ml | ELISA: 0.01-0.1 ug/ml | IP: 2-5 ug/ml | IHC: 2-10 ug/ml | FC: Not tested |
| Immunogen |
A synthetic peptide derived from C-terminus of ERK2 protein from human, rat, mouse and dog origins. |
| Additional Information |
Cellular Location: Cytoplasmic |
| Formulation |
This affinity purified antibody is supplied in sterile Phosphatebuffered saline (pH7.2) containing antibody stabilizer |
| Uniprot ID |
O14493 |
| Purification |
Affinity Purified |
| Gene Symbol |
MAPK1 |
| Predicted Species Reactivity |
Human|Mouse|Rat |
| Application |
Enzyme-linked immunosorbent assay|Flow cytometry|Immunohistochemistry|Immunoprecipitation|Western blot |
| Image 1 | Human Breast carcinoma
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