| Product Number |
OAAH00023 |
| Product Page |
www.avivasysbio.com/isg15-9a1-mouse-mab-oaah00023.html |
| Name |
ISG15 (9A1) Mouse mAb (OAAH00023) |
| Molecular Weight |
15 kDa |
| Isotype |
Mouse IgG |
| NCBI Gene Id |
9636 |
| Host |
Mouse |
| Clonality |
Monoclonal |
| Source |
Mouse mAb |
| Alias Symbols |
G1P2, IP17, UCRP, IFI15, IMD38, hUCRP |
| Reference |
1. Blomstrom DC, Fahey D, Kutny R, Korant BD, Knight Jr E. Molecular
characterization of the interferon-induced 15-kDa protein. Molecular cloning
and nucleotide and amino acid sequence. J Biol Chem 1986;261:88116.
2. Au WC, Moore PA, Lowther W, Juang YT, Pitha PM. Identification of a
member of the interferon regulatory factor family that binds to the
interferon-stimulated response element and activates expression of
interferon-induced genes. Proc Natl Acad Sci USA 1995;92:1165761. |
| Description of Target |
ISG15 (Interferon Stimulating Gene 15, also known as Ubiquitin Cross-reactive Protein (UCRP) is an 15 kDa ubiquitin-like protein containing two ubiquitin homology domains. ISC15 is induced to express in response to IFN alpha or IFN beta, but not IFN gamma. ISG15 post-translationally modifies proteins via a pathway parallel to, and partially overlapping with, that of ubiquitin. In addition, ISG15 is released from cells to mediate extracellular cytokine-like activities. Its modification system plays important roles in the innate immune response, regulation of interferon signaling, pregnancy, and several cancers. |
| Reconstitution and Storage |
Store the product at -20C. Stable for one year from the date of shipment. |
| Datasheets/Manuals |
Printable datasheet for ISG15 (9A1) Mouse mAb (OAAH00023) OAAH00023 |
| Specificity |
ISG15 (9A1) Mouse mAb detects endogenous level of total ISG15 protein. |
| Application Info |
WB: 1:1000 |
| Immunogen |
This Aviva monoclonal antibody is produced by immunizing mice with humanISG15 full-length protein. |
| Uniprot ID |
P05161 |
| Protein Name |
Ubiquitin-like protein ISG15 |
| Gene Symbol |
ISG15 |
| Predicted Species Reactivity |
Human |
| Application |
SDS-PAGE, WB |
| Image 1 | Recombinant His-tagged
 | Recombinant His-tagged ISG15 (20 kDa) and ubiquitin (14 kDa) were resolved by SDS-PAGE, and probed with ISG15 (9A1) Mouse mAb (top panel) or with anti Ub (bottom panel). |
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