| Product Number |
OAAD00405 |
| Product Page |
www.avivasysbio.com/mcl-1-antibody-oaad00405.html |
| Name |
MCL1 Antibody (OAAD00405) |
| Clone |
8C6D4B1 |
| Isotype |
IgG1 |
| NCBI Gene Id |
4170 |
| Clonality |
Monoclonal |
| Concentration |
1 mg/ml |
| Alias Symbols |
TM, EAT, MCL1L, MCL1S, Mcl-1, BCL2L3, MCL1-ES, bcl2-L-3, mcl1/EAT |
| Product Format |
Liquid |
| Reference |
1. Ota, N. et al. J. Hum.
Genet. 2000. 46: 254-269.
2. Schwertfeger KL, Ryder JW, Anderson SM J Mammary Gland Biol Neoplasia 2000, 3 : 236-251. |
| Description of Target |
Mcl-1 (Myeloid cell leukemia-1) is Bcl-2-related and was identi?ed as an early-induction gene that increased in expression during the differentiation of human myeloblastic leukemia cell ML-1, or exposure to different DNA damaging agents. The level of Mcl1 is decreased in peripheral B lymphocytes undergoing apoptosis following treatment with apoptotic stimuli such as TGF-alpha 1 and forskolin. Expression of Mcl-1 is able to delay apoptosis induced by over-expression of c-myc in CHO 5AHSmyc cells. In hematopoietic FDC-P1 cells, Mcl-1 interacts with another Bcl-2-related protein, Bax, and prolongs cell viability after treatment with different apoptotic reagents.This monoclonal antibody detected a 37kd MCL1 in BCBL-1 cell lysate. |
| Reconstitution and Storage |
Store at -20°C |
| Datasheets/Manuals |
Printable datasheet for MCL-1 Antibody (OAAD00405) - OAAD00405 |
| Application Info |
WB: 1: 200- 1: 1,000
IHC-P: 1: 200- 1: 1,000
IHC-F: 1: 200- 1: 1,000
ELISA: 1: 10,000
Optimal dilutions should be determined by the end user. |
| Immunogen |
Ni-NTA purified recombinant protein MCL-1 expressed in E. Coli strain M15. |
| Uniprot ID |
Q07820 |
| Protein Name |
Induced myeloid leukemia cell differentiation protein Mcl-1 |
| Purification |
Antibodies are puri?ed by protein G af?nity chromatography |
| Gene Symbol |
MCL1 |
| Predicted Species Reactivity |
Human |
| Application |
WB, IHC-P, IHC-F |
| Image 1 | BCBL-1
 | western blot analysis using anti-human MCL-1 monoclonal antibody against BCBL-1 cell lysate. |
| | Image 2 | Human lymph node
 | Immunohistochemical analysis of paraffin-embedded Human lymph node tissue showing cytoplasmic localization using MCL-1 antibody with DAB staining. |
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