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MCL1 Antibody (OAAD00405)

0.1 mg
$290.00
In Stock
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Predicted Species Reactivity:
Human
Product Format:
Liquid
Clonality:
Monoclonal
Clone:
8C6D4B1
Isotype:
IgG1
Application:
WB, IHC-P, IHC-F, ELISA
Reconstitution and Storage:
Store at -20°C
Gene Symbol:
MCL1
NCBI Gene Id:
4170
Protein Name:
Induced myeloid leukemia cell differentiation protein Mcl-1
Swissprot Id:
Q07820
Alias Symbols:
Induced myeloid leukemia cell differentiation protein Mcl-1, Bcl-2-like protein 3, Bcl-2-related protein EAT/mcl1, TM, EAT, MCL1L, MCL1S, Mcl-1, BCL2L3, MCL1-ES, bcl2-L-3, mcl1/EAT
Replacement Item:
This antibody may replace item sc-121559, HPA008455
Description of Target:
Mcl-1 (Myeloid cell leukemia-1) is Bcl-2-related and was identified as an early-induction gene that increased in expression during the differentiation of human myeloblastic leukemia cell ML-1, or exposure to different DNA damaging agents. The level of Mcl1 is decreased in peripheral B lymphocytes undergoing apoptosis following treatment with apoptotic stimuli such as TGF-alpha 1 and forskolin. Expression of Mcl-1 is able to delay apoptosis induced by over-expression of c-myc in CHO 5AHSmyc cells. In hematopoietic FDC-P1 cells, Mcl-1 interacts with another Bcl-2-related protein, Bax, and prolongs cell viability after treatment with different apoptotic reagents.This monoclonal antibody detected a 37kd MCL1 in BCBL-1 cell lysate.
Purification:
Antibodies are purified by protein G affinity chromatography
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express MCL1.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express MCL1.
Immunogen:
Ni-NTA purified recombinant protein MCL-1 expressed in E. Coli strain M15.
Concentration:
1 mg/ml
Datasheets/Manuals:
Printable datasheet for MCL-1 Antibody (OAAD00405) - OAAD00405
Application Info:
WB: 1: 200- 1: 1,000
IHC-P: 1: 200- 1: 1,000
IHC-F: 1: 200- 1: 1,000
ELISA: 1: 10,000
Optimal dilutions should be determined by the end user.
Target Reference:
1. Ota, N. et al. J. Hum.
Genet. 2000. 46: 254-269.
2. Schwertfeger KL, Ryder JW, Anderson SM J Mammary Gland Biol Neoplasia 2000, 3 : 236-251.

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