| Product Number |
OAAB17429 |
| Product Page |
www.avivasysbio.com/mlklak-antibody-center-region-oaab17429.html |
| Name |
MLKLAK Antibody - middle region (OAAB17429) |
| Molecular Weight |
91155 Da |
| Isotype |
Ig |
| NCBI Gene Id |
51776 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
Approximately 0.5mg/ml. Actual concentration varies with each lot. |
| Alias Symbols |
pk, AZK, MLT, MRK, ZAK, CNM6, MLK7, MLTK, SFMMP, mlklak, MLTKbeta, MLTKalpha |
| Product Format |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Description of Target |
Purified Rabbit Polyclonal Antibody (Pab) |
| Reconstitution and Storage |
Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for OAAB17429 |
| Additional Information |
Precautions: MLKLAK Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Additional Information |
Function: Stress-activated component of a protein kinase signal transduction cascade. Regulates the JNK and p38 pathways. Pro- apoptotic. Role in regulation of S and G2 cell cycle checkpoint by direct phosphorylation of CHEK2. Isoform 1, but not isoform 2, causes cell shrinkage and disruption of actin stress fibers Isoform 1 may have role in neoplastic cell transformation and cancer development. Isoform 1, but not isoform 2, phosphorylates histone H3 at 'Ser-28' |
| Application Info |
WB: 1:1000
IHC-P: 1:50~100 |
| Immunogen |
This MLKLAK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 271-300 amino acids from the Central region of human MLKLAK. |
| Additional Information |
Cellular Location: Cytoplasm. Nucleus. Note=Translocates to the nucleus upon ultraviolet B irradiation
Tissue Location: Ubiquitously expressed. Isoform 2 is the predominant form in all tissues examined, except for liver, in which isoform 1 is more highly expressed |
| Uniprot ID |
Q9NYL2 |
| Protein Name |
Mitogen-activated protein kinase kinase kinase MLT |
| Protein Accession # |
NP_057737.2 |
| Gene Symbol |
MLTK |
| Predicted Species Reactivity |
Human |
| Application |
WB |
| Predicted Homology Based on Immunogen Sequence |
Human |
| Image 1 | HepG2
 | Western blot analysis of anti-MLKLAK-C284 Pab (Cat. # OAAB17429) in HepG2 cell line lysate (35ug/lane). MLKLAK-C284(arrow) was detected using the purified Pab (1:60 dilution). This western blot detected isoform 2 of MLKLAK, the accession number for MLKLAK isoform 1 is Q9NYL2, NP_057737. |
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