MLKLAK Antibody - middle region (OAAB17429)

Catalog No: OAAB17429

Size:400ul

Western blot analysis of anti-MLKLAK-C284 Pab (Cat. # OAAB17429) in HepG2 cell line lysate (35ug/lane). MLKLAK-C284(arrow) was detected using the purified Pab (1:60 dilution). This western blot detected isoform 2 of MLKLAK, the accession number for MLKLAK isoform 1 is Q9NYL2, NP_057737.

Product Info

• Predicted Species Reactivity: Human
• Product Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
• Clonality: Polyclonal
• Isotype: Ig
• Host: Rabbit
• Application: WB
• Additional Information: Precautions: MLKLAK Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
  Function: Stress-activated component of a protein kinase signal transduction cascade. Regulates the JNK and p38 pathways. Pro- apoptotic. Role in regulation of S and G2 cell cycle checkpoint by direct phosphorylation of CHEK2. Isoform 1, but not isoform 2, causes cell shrinkage and disruption of actin stress fibers Isoform 1 may have role in neoplastic cell transformation and cancer development. Isoform 1, but not isoform 2, phosphorylates histone H3 at 'Ser-28'
  Cellular Location: Cytoplasm. Nucleus. Note=Translocates to the nucleus upon ultraviolet B irradiation
  Tissue Location: Ubiquitously expressed. Isoform 2 is the predominant form in all tissues examined, except for liver, in which isoform 1 is more highly expressed
• Reconstitution and Storage: Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: This MLKLAK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 271-300 amino acids from the Central region of human MLKLAK.
• Predicted Homology Based on Immunogen Sequence: Human
• Concentration: Approximately 0.5mg/ml. Actual concentration varies with each lot.
• Application Info: WB: 1:1000
  IHC-P: 1:50~100

Target Info

• Gene Symbol: MLTK
• Alias Symbols: pk, AZK, MLT, MRK, ZAK, CNM6, MLK7, MLTK, SFMMP, mlklak, MLTKbeta, MLTKalpha
• NCBI Gene Id: 51776
• Protein Name: Mitogen-activated protein kinase kinase kinase MLT
• Description of Target: Purified Rabbit Polyclonal Antibody (Pab)
• Uniprot ID: Q9NYL2
• Protein Accession #: NP_057737.2
• Molecular Weight: 91155 Da