ATRX Antibody - C-terminal region (ARP47775_P050)

• Product Number: ARP47775_P050
• Name: ATRX Antibody - C-terminal region (ARP47775_P050)
• Protein Size (# AA): 1350 amino acids
• Molecular Weight: 148kDa
• NCBI Gene Id: 546
• Host: Rabbit
• Clonality: Polyclonal
• Concentration: 0.5 mg/ml
• Gene Full Name: similar to putative DNA dependent ATPase and helicase
• Alias Symbols: JMS, XH2, XNP, MRX52, RAD54, RAD54L, ZNF-HX
• Peptide Sequence: Synthetic peptide located within the following region: DQSDETSEDDKKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPE
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Description of Target: The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. The mutations of this gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.
• Protein Interactions: SUMO2; SUMO3; RAD51; H3F3A; PRKDC; PML; NBN; MRE11A; HIST1H1C; XRCC6; DAXX; SUPT16H; RAD50; HIST1H4J; HIST2H2BE; HIST1H2BL; HIST1H2AB; XRCC5; TP53; SSRP1; RPA1; RAD9A; RAD1; ZNF512B; UL82; NEK1; BLM; HIST2H3C; ZBED1; UBC; SVIL; CALM1; WRN; HIST1H3A; CBX5;
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Blocking Peptide: For anti-ATRX (ARP47775_P050) antibody is Catalog # AAP47775
• Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human ATRX
• Uniprot ID: P46100-6
• Protein Name: Transcriptional regulator ATRX
• Sample Type Confirmation:

  ATRX is strongly supported by BioGPS gene expression data to be expressed in Jurkat

• Purification: Affinity Purified
• Tested Species Reactivity: Human
• Gene Symbol: ATRX
• Predicted Species Reactivity: Human, Dog, Pig, Rabbit
• Application: WB
• Predicted Homology Based on Immunogen Sequence: Dog: 88%; Human: 100%; Pig: 93%; Rabbit: 75%
• Image 1: Human Jurkat
  
  Host: Rabbit
  Target Name: ATRX
  Sample Type: Jurkat Whole Cell lysates
  Antibody Dilution: 1.0ug/mlATRX is strongly supported by BioGPS gene expression data to be expressed in Human Jurkat cells