| Product Number |
ARP32043_P050 |
| Product Page |
www.avivasysbio.com/nfkb2-antibody-c-terminal-region-arp32043-p050.html |
| Name |
NFKB2 Antibody - C-terminal region (ARP32043_P050) |
| Protein Size (# AA) |
900 amino acids |
| Molecular Weight |
97kDa |
| NCBI Gene Id |
4791 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
0.5 mg/ml |
| Gene Full Name |
Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) |
| Alias Symbols |
p52, p100, H2TF1, LYT10, CVID10, LYT-10, NF-kB2, p49/p100 |
| Peptide Sequence |
Synthetic peptide located within the following region: SDSDSDSEGPEKDTRSSFRGHTPLDLTCSTLVKTLLLNAAQNTMEPPL |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reference |
Xiao,G., et al., (2004) J. Biol. Chem. 279 (29), 30099-30105 |
| Description of Target |
NFKB has been detected in numerous cell types that express cytokines, chemokines, growth factors, cell adhesion molecules, and some acute phase proteins in health and in various disease states. NFKB is activated by a wide variety of stimuli such as cytokines, oxidant-free radicals, inhaled particles, ultraviolet irradiation, and bacterial or viral products. Inappropriate activation of NF-kappa-B has been linked to inflammatory events associated with autoimmune arthritis, asthma, septic shock, lung fibrosis, glomerulonephritis, atherosclerosis, and AIDS. In contrast, complete and persistent inhibition of NF-kappa-B has been linked directly to apoptosis, inappropriate immune cell development, and delayed cell growth. |
| Protein Interactions |
FBXW11; UBC; RELB; RELA; REL; NFKB1; CHUK; BCL3; SUMO1; NEDD8; TNFAIP3; BIRC2; EPS8; VCP; UBD; BRRF1; COMMD1; COMMD2; MAP3K14; BTRC; NFKB2; FBXW7; TSG101; IKBKG; SUMO2; DPF2; PSMD11; NFKBIZ; TNIP2; HDAC5; NFKBIB; HDAC4; USP2; NFKBIE; RPL6; IKBKB; TSC22D3; |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-NFKB2 (ARP32043_P050) antibody |
| Blocking Peptide |
For anti-NFKB2 (ARP32043_P050) antibody is Catalog # AAP32043 (Previous Catalog # AAPP02945) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the C terminal region of human NFKB2 |
| Uniprot ID |
Q00653 |
| Protein Name |
Nuclear factor NF-kappa-B p100 subunit |
| Publications |
Volger, O. L. et al. Distinctive expression of chemokines and transforming growth factor-beta signaling in human arterial endothelium during atherosclerosis. Am. J. Pathol. 171, 326-37 (2007). 17591977
Wang, C.-Y., Yang, P., Li, M. & Gong, F. Characterization of a negative feedback network between SUMO4 expression and NFkappaB transcriptional activity. Biochem. Biophys. Res. Commun. 381, 477-81 (2009). 19222990 |
| Protein Accession # |
NP_002493 |
| Purification |
Affinity Purified |
| Nucleotide Accession # |
NM_002502 |
| Tested Species Reactivity |
Human |
| Gene Symbol |
NFKB2 |
| Predicted Species Reactivity |
Human, Rat, Cow, Horse, Pig, Rabbit |
| Application |
IHC, WB |
| Predicted Homology Based on Immunogen Sequence |
Cow: 77%; Horse: 85%; Human: 100%; Pig: 77%; Rabbit: 92%; Rat: 77% |
| Image 1 | Human Muscle
 | Human Muscle |
|
| Image 2 | Human Smooth Muscle
 | Human Smooth Muscle |
|
| Image 3 | Human HCT116
 | Host: Rabbit
Target Name: NFKB2
Sample Tissue: Human HCT116
Antibody Dilution: 1.0ug/ml |
|
