| Sku |
AAP58516 |
| Old sku |
AAPP34724 |
| Price |
$99.00 |
| Name |
PPP4C Peptide - middle region (AAP58516) |
| Purchase info |
To purchase this peptide:
- Copy peptide sku
- Click on this link
- Paste into field "Peptide Sku"
|
| Size |
100 ug |
| Gene |
PPP4C |
| Alias symbols |
PP4, PPH3, PPX, PP4C, PPP4 |
| Gene id |
5531 |
| Description of target |
PPP4C is a protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA DSB repair. Dephosphorylates NDEL1 at CDC2/Cdk1 phosphorylation sites and negatively regulates CDC2/Cdk1 activity in interphase. |
| Swissprot id |
P60510 |
| Protein accession num |
NP_002711 |
| Nucleotide accession num |
NM_002720 |
| Protein size |
307 amino acids |
| Molecular weight |
34kDa |
| Application |
WB |
| Partner proteins |
HDAC3,CCDC6,DHX38,HDAC3,IGBP1,NFKB1,PPP2R1A,PPP2R5D,PPP4R1,PPP4R2,PPP4R4,REL,RELA,SMEK2,TMSB4X,BAT3,CCDC6,CCT2,CCT3,CCT4,CCT5,CCT6A,CCT7,CCT8,DHX38,GEMIN4,IGBP1,JUN,NFKB1,PPP2CB,PPP2R1A,PPP2R5D,PPP4R1,PPP4R2,PPP4R4,REL,RELA,SMEK1,SMEK2,SMN1,TCP1,TIPRL,TLR4,TP53,TRAF6 |
| Quality control |
The peptide is characterized by mass spectroscopy |
| Key reference |
Humphray,S.J., (2008) J. Cell Biol. 180 (6), 1133-1147 |
| Description |
This is a synthetic peptide designed for use in combination with anti-PPP4C antibody (Catalog #: ARP58516_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details. |
| Product format |
Lyophilized powder |
| Reconstitution and storage |
Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles. |
| Lead time |
Domestic: within 24 hours delivery International: 3-5 business days |
| Protocol |
|
| Tips |
See our General FAQ page. |
| Availability |
In Stock |
