| Sku |
AAP56224 |
| Old sku |
AAPP38142 |
| Price |
$99.00 |
| Name |
MBP Peptide - middle region (AAP56224) |
| Purchase info |
To purchase this peptide:
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|
| Size |
100 ug |
| Gene |
MBP |
| Alias symbols |
MGC99675 |
| Gene id |
4155 |
| Description of target |
The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. MBP induces T-cell proliferation.The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called 'Golli-MBP') that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes. |
| Swissprot id |
P02686 |
| Protein accession num |
NP_001020272 |
| Nucleotide accession num |
NM_001025101 |
| Protein size |
304 amino acids |
| Molecular weight |
33kDa |
| Application |
IHC, IP, WB |
| Partner proteins |
MAPK1,PRKCA,PRKCD,PRKCI,PRKCZ,ROCK1,ROCK2,APTX,ATN1,ATXN1,BMP2K,CDK12,CLK1,CTDSP1,DYRK1B,EFHA1,HLA-DRA,IRAK1,MAG,MAPK1,MAPK11,MAPK13,MAPK14,MAPK15,MAPK3,MAPKAPK5,MELK,MKNK1,MMP7,MST4,NEK9,PAK1,PLP1,PRKACA,PRKCA,PRKCD,PRKCI,PRKCZ,PRMT1,PRMT5,RAN,RPS6KA5,RTN4,SRPK1,STK16,STK39,STK4,TLK1,TLK2,TRAF6,TRPM7,HLA-DRA,PLP1,PRMT5,STK39,TRPM7 |
| Quality control |
The peptide is characterized by mass spectroscopy |
| Key reference |
Zhang,Q.Y., (2008) Arch. Med. Res. 39 (1), 45-51 |
| Description |
This is a synthetic peptide designed for use in combination with anti-MBP antibody (Catalog #: ARP56224_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details. |
| Product format |
Lyophilized powder |
| Reconstitution and storage |
Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles. |
| Lead time |
Domestic: within 24 hours delivery International: 3-5 business days |
| Protocol |
|
| Tips |
See our General FAQ page. |
| Availability |
In Stock |
