| Sku |
AAP56117 |
| Old sku |
AAPP37738 |
| Price |
$99.00 |
| Name |
PMS2 Peptide - middle region (AAP56117) |
| Purchase info |
To purchase this peptide:
- Copy peptide sku
- Click on this link
- Paste into field "Peptide Sku"
|
| Size |
100 ug |
| Gene |
PMS2 |
| Alias symbols |
HNPCC4, PMS2CL, PMSL2 |
| Gene id |
5395 |
| Description of target |
PMS2 is involved in DNA mismatch repair. It forms a heterodimer with MLH1 and this complex interacts with other complexes bound to mismatched bases. Mutations in this gene are associated with hereditary nonpolyposis colorectal cancer, Turcot syndrome, and are a cause of supratentorial primitive neuroectodermal tumors.This gene is one of the PMS2 gene family members found in clusters on chromosome 7. The product of this gene is involved in DNA mismatch repair. It forms a heterodimer with MLH1 and this complex interacts with other complexes bound to mismatched bases. Mutations in this gene are associated with hereditary nonpolyposis colorectal cancer, Turcot syndrome, and are a cause of supratentorial primitive neuroectodermal tumors. Alternatively spliced transcript variants have been observed for this gene. |
| Swissprot id |
P54278 |
| Protein accession num |
NP_000526 |
| Nucleotide accession num |
NM_000535 |
| Protein size |
862 amino acids |
| Molecular weight |
96kDa |
| Application |
WB |
| Partner proteins |
EXO1,MLH1,EXO1,MLH1,AIFM1,ATAD3A,BRCA2,BRIP1,COPB1,COPG,COPG2,CYLD,DDB1,EXO1,KPNA2,KPNB1,MCM3,MLH1,MMS19,MSH2,MSH3,MSH6,MTMR15,NSUN2,PCNA,PIK3C2A,PPP2CA,PRKDC,PSD2,PSD3,PSMC1,PSMC2,PSMC3,PSMC6,PSMD5,RFC2,RUVBL1,RUVBL2,SMARCA4,UBC,UBR5,XPO1 |
| Quality control |
The peptide is characterized by mass spectroscopy |
| Key reference |
Jackson,C.C., (2008) Pediatr Blood Cancer 50 (6), 1268-1270 |
| Description |
This is a synthetic peptide designed for use in combination with anti-PMS2 antibody (Catalog #: ARP56117_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details. |
| Product format |
Lyophilized powder |
| Reconstitution and storage |
Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles. |
| Lead time |
Domestic: within 24 hours delivery International: 3-5 business days |
| Protocol |
|
| Tips |
See our General FAQ page. |
| Availability |
In Stock |
