| Sku |
AAP54921 |
| Old sku |
AAPP31876 |
| Price |
$99.00 |
| Name |
TBK1 Peptide (AAP54921) |
| Purchase info |
To purchase this peptide:
- Copy peptide sku
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- Paste into field "Peptide Sku"
|
| Size |
100 ug |
| Gene |
TBK1 |
| Alias symbols |
FLJ11330, NAK, T2K |
| Gene id |
29110 |
| Description of target |
The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. TBK1 is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors. For example, the protein can form a complex with the IKB protein TANK and TRAF2 and release the NFKB inhibition caused by TANK. The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors. For example, the protein can form a complex with the IKB protein TANK and TRAF2 and release the NFKB inhibition caused by TANK. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. |
| Swissprot id |
Q9UHD2 |
| Protein accession num |
NP_037386 |
| Nucleotide accession num |
NM_013254 |
| Protein size |
729 amino acids |
| Molecular weight |
84kDa |
| Application |
WB |
| Partner proteins |
TICAM1,AZI2,CDC37,HSP90AA1,HSP90AB1,IKBKB,IKBKG,IRF3,IRF5,MAVS,NCK1,NFKBIA,RELA,SIKE1,TANK,TBK1,TICAM1,TRAF2,ANKRD28,BTRC,CDC37,CUL1,CYLD,HSP90AA2,IKBKG,IRF3,NCK1,NFKB1,NFKB2,PPP6C,PPP6R1,PPP6R2,REL,RELA,SKP1,TANK,TBKBP1,TNFAIP3,TRAF2,TRAF3,UBC |
| Quality control |
The peptide is characterized by mass spectroscopy |
| Key reference |
Morton,S., (2008) FEBS Lett. 582 (6), 997-1002 |
| Description |
This is a synthetic peptide designed for use in combination with anti-TBK1 antibody (Catalog #: ARP54921_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details. |
| Product format |
Lyophilized powder |
| Reconstitution and storage |
Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles. |
| Lead time |
Domestic: within 24 hours delivery International: 3-5 business days |
| Protocol |
|
| Tips |
See our General FAQ page. |
| Availability |
In Stock |
