| Sku |
AAP54630 |
| Old sku |
AAPP31421 |
| Price |
$99.00 |
| Name |
GNAI1 Peptide (AAP54630) |
| Purchase info |
To purchase this peptide:
- Copy peptide sku
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|
| Size |
100 ug |
| Gene |
GNAI1 |
| Alias symbols |
Gi |
| Gene id |
2770 |
| Description of target |
Guanine nucleotide-binding proteins (G proteins) form a large family of signal-transducing molecules. They are found as heterotrimers made up of alpha, beta, and gamma subunits. Members of the G protein family have been characterized most extensively on the basis of the alpha subunit, which binds guanine nucleotide, is capable of hydrolyzing GTP, and interacts with specific receptor and effector molecules. The G protein family includes Gs and Gi, the stimulatory and inhibitory GTP-binding regulators of adenylate cyclase; Go, a protein abundant in brain (GNAO1); and transducin-1 (GNAT1) and transducin-2 (GNAT2), proteins involved in phototransduction in retinal rods and cones, respectively.Guanine nucleotide-binding proteins (G proteins) form a large family of signal-transducing molecules. They are found as heterotrimers made up of alpha, beta, and gamma subunits. Members of the G protein family have been characterized most extensively on the basis of the alpha subunit, which binds guanine nucleotide, is capable of hydrolyzing GTP, and interacts with specific receptor and effector molecules. The G protein family includes Gs (MIM 139320) and Gi, the stimulatory and inhibitory GTP-binding regulators of adenylate cyclase; Go, a protein abundant in brain (GNAO1; MIM 139311); and transducin-1 (GNAT1; MIM 139330) and transducin-2 (GNAT2; MIM 139340), proteins involved in phototransduction in retinal rods and cones, respectively (Sullivan et al., 1986 [PubMed 3092218]; Bray et al., 1987 [PubMed 3110783]). Suki et al. (1987) [PubMed 2440724] concluded that the human genome contains at least 3 nonallelic genes for alpha-i-type subunits of G protein; see, e.g, GNAI2 (MIM 139360), GNAI3 (MIM 139370), and GNAIH (MIM 139180).[supplied by OMIM]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. |
| Swissprot id |
P63096 |
| Protein accession num |
NP_002060 |
| Nucleotide accession num |
NM_002069 |
| Protein size |
354 amino acids |
| Molecular weight |
40kDa |
| Application |
WB |
| Partner proteins |
GPSM2,NUMA1,ADCY5,ADRA2A,CCR5,CD47,CNR1,CRHR1,CXCR4,DRD3,EPOR,ESR1,FFAR1,GNAI1,GNAO1,GPR1,GPR143,GPSM2,GPSM3,HRH4,HTR2A,IGF1R,KLHL3,MTNR1A,MTNR1B,NGB,NUMA1,OPRD1,OPRM1,PDE6D,PTPRU,RASD1,RGS10,RGS12,RGS14,RGS16,RGS18,RGS19,RGS20,RGS4,RGS7,RIC8A,S1PR1,S1PR2,S1PR3,S1PR4,S1PR5,SSTR2,SSTR3,STRN,TSHR,VIPR1,WASF1,ADCY5,CNR1,CRHR1,EPOR,GPR143,GPSM1,GPSM3,IGF1R,NGB,RASD1,RGS10,RGS12,RGS14,RGS16,RGS18,RGS19,RGS4,RGS5,RIC8A,S1PR1 |
| Subunit |
alpha-1 |
| Quality control |
The peptide is characterized by mass spectroscopy |
| Key reference |
Hurst,J.H., (2008) Cell. Signal. 20 (2), 381-389 |
| Description |
This is a synthetic peptide designed for use in combination with anti-GNAI1 antibody (Catalog #: ARP54630_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details. |
| Product format |
Lyophilized powder |
| Reconstitution and storage |
Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles. |
| Lead time |
Domestic: within 24 hours delivery International: 3-5 business days |
| Protocol |
|
| Tips |
See our General FAQ page. |
| Availability |
In Stock |
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