| Sku |
AAP52067 |
| Old sku |
AAPP30292 |
| Price |
$99.00 |
| Name |
CTTN Peptide (AAP52067) |
| Purchase info |
To purchase this peptide:
- Copy peptide sku
- Click on this link
- Paste into field "Peptide Sku"
|
| Size |
100 ug |
| Gene |
CTTN |
| Alias symbols |
EMS1, FLJ34459 |
| Gene id |
2017 |
| Description of target |
CTTN is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. CTTN is localized in the cytoplasm and in areas of the cell-substratum contacts. It has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, CTTN is degraded in a caspase-dependent manner. The aberrant regulation of t CTTN contributes to tumor cell invasion and metastasis.This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Two splice variants that encode different isoforms have been identified for this gene. |
| Swissprot id |
Q8N707 |
| Protein accession num |
NP_005222 |
| Nucleotide accession num |
NM_005231 |
| Protein size |
550 amino acids |
| Molecular weight |
61kDa |
| Application |
IHC, WB |
| Partner proteins |
ARHGAP8,ACTA1,ACTR3,ANKZF1,CHD3,CTNND1,CTNND2,CTTN,CTTNBP2,DNM1,DNM2,FER,FGD1,GRB2,HAX1,HIP1R,KCNA2,MET,MYLK,NCF1,SDC3,SHANK2,SRC,SYK,TJP1,WIPF1,ACTR2,ACTR3,ARHGAP17,ARPC2,ARPC3,ARPC4,ASAP1,CASP3,CHD3,CRB2,CTNND1,FER,KCNA2,MYLK,PXN,SDC3,SHANK2,SYK,WASL,WIPF1 |
| Quality control |
The peptide is characterized by mass spectroscopy |
| Key reference |
Ma,S.F., (er) Genet. Epidemiol. (2008) In press |
| Description |
This is a synthetic peptide designed for use in combination with anti-CTTN antibody (Catalog #: ARP52067_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details. |
| Product format |
Lyophilized powder |
| Reconstitution and storage |
Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles. |
| Lead time |
Domestic: within 24 hours delivery International: 3-5 business days |
| Protocol |
|
| Tips |
See our General FAQ page. |
| Availability |
In Stock |
