| Sku |
AAP36016 |
| Old sku |
AAPP07326 |
| Price |
$99.00 |
| Name |
NR1I2 Peptide - N-terminal region (AAP36016) |
| Purchase info |
To purchase this peptide:
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|
| Size |
100 ug |
| Gene |
NR1I2 |
| Alias symbols |
BXR, ONR1, PAR, PAR1, PAR2, PARq, PRR, PXR, SAR, SXR |
| Gene id |
8856 |
| Description of target |
NR1I2 belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. NR1I2 contains a zinc finger domain.NR1I2 is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. NR1I2 belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized. |
| Swissprot id |
O75469 |
| Protein accession num |
NP_003880 |
| Nucleotide accession num |
NM_003889 |
| Protein size |
434 amino acids |
| Molecular weight |
50kDa |
| Application |
IHC, WB |
| Partner proteins |
ACTN2,NCOA1,NCOA3,NCOR2,NR1I2,NUCB2,POU1F1,PPARGC1A,PSMC5,RXRA,RXRB,RXRG,SRC,NCOA1,POU1F1 |
| Quality control |
The peptide is characterized by mass spectroscopy |
| Key reference |
Hesselink,D.A., (2008) Pharmacogenomics 9 (6), 783-789 |
| Description |
This is a synthetic peptide designed for use in combination with anti-NR1I2 antibody (Catalog #: ARP36016_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details. |
| Product format |
Lyophilized powder |
| Reconstitution and storage |
Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles. |
| Lead time |
Domestic: within 24 hours delivery International: 3-5 business days |
| Protocol |
|
| Tips |
See our General FAQ page. |
| Availability |
In Stock |
