AKT1 Peptide (AAP30466)

Data Sheet
 
Sku AAP30466
Old sku AAPP01102
Price $99.00
Name AKT1 Peptide (AAP30466)
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Size 100 ug
Gene AKT1
Alias symbols AKT, PKB, RAC, PRKBA, PKB-ALPHA, RAC-ALPHA
Gene id 207
Description of target AKT1 is a general protein kinase capable of phosphorylating several known proteins.The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Multiple alternatively spliced transcript variants have been found for this gene.
Swissprot id P31749
Protein accession num NP_005154
Nucleotide accession num NM_005163
Protein size 480 amino acids
Molecular weight 56kDa
Application WB
Partner proteins APPL1,AR,FOXO4,GSK3B,HTT,IMPDH2,MDM2,NCF1C,PDK1,PDPK1,PEA15,PIAS2,PRKDC,TCL1A,TCL1B,TSC2,YWHAZ,YWHAZ,CSNK2A1,METTL1,PHLPP1,YBX1,AHNAK,AKT1,AKT1S1,AKT2,AKTIP,APLP2,APPL1,AR,ATXN1,BAD,BCL10,BCL2L11,BRAF,BRCA1,CAMKK1,CASP3,CASP9,CCDC88A,CDKN1A,CDKN1B,CHEK1,CHUK,CREB1,DLC1,EIF4EBP1,EP300,ESR1,ESR2,EZH2,FANCA,FOXO1,FOXO3,FOXO4,GAB2,GATA1,GATA2,GRB10,GSK3A,GSK3B,HIST2H2BE,HMOX1,HSP90AA1,HSP90AB1,HTT,IKBKB,ILK,IMPDH2,IRAK1,IRS1,ITGB3,KRT10,MAP2K4,MAP3K11,MAP3K5,MAP3K8,MAPK8IP1,MAPKAPK2,MDM2,MDM4,METTL1,MS4A2,MST1R,MTCP1,MTOR,NCF1,NOS3,NR4A1,PAK1,PDE3B,PDK2,PDPK1,PEA15,PFKFB2,PHB2,PIK3R1,PKN2,PLXNA1,PPARGC1B,PPL,PPM1A,PPP2CA,PRG2,PRKCQ,PRKCZ,PRKDC,PTEN,PTPN1,RAB3D,RAC1,RAF1,RHEBL1,RPS6KB1,S1PR1,SH2B2,SMAD2,SMAD3,SMAD4,SMAD7,SORBS2,SRC,STAT1,TCL1A,TCL1B,TERT,THEM4,TNFSF11,TOPBP1,TRIB3,TSC1,TSC2,UXS1,VEGFA,WNK1,XIAP,YAP1,YBX1,YWHAZ,AKTIP,AR,ARFIP2,ARHGAP29,ARHGAP32,Akt2,BAD,BRAF,BRCA1,CARHSP1,CDKN1B,CHN2,CHUK,FANCA,GAB2,GSK3B,HSP90AA1,HSP90AB1,HSPB1,ILK,ILK,IMPDH2,IRAK1,IRS1,KRT10,KTN1,MAP2K4,MAP3K11,MAP3K8,MAPK14,MAPK8IP1,MAPKAP1,MAPKAPK2,MARK2,MTCP1,MTOR,NF2,NPM1,NR4A1,PAK1,PAK6,PDPK1,PIAS1,PIAS2,PKN2,PLXNA1,PLXNB1,PRKCQ,PRKCZ,RAF1,RICTOR,RPS6KB1,SMAD2,SMAD3,SMAD4,SMAD7,STUB1,TCL1A,TCL1B,TERT,THEM4,TRIB3,TSC1,TSC2,UBC,USP8,YWHAZ
Quality control The peptide is characterized by mass spectroscopy
Key reference Jones, P.F., et al., (1991) Proc. Natl. Acad. Sci. U.S.A. 88: 4171-4175.
Description This is a synthetic peptide designed for use in combination with anti-AKT1 antibody (Catalog #: AVARP06008_T100) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
Product format Lyophilized powder
Reconstitution and storage Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles.
Lead time Domestic: within 24 hours delivery  International: 3-5 business days
Protocol
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AVIVA SYSTEMS BIOLOGY manufactures and sells quality antibody products covering genome wide proteins.

This product is for Research Use Only. Not for diagnostic, human, or veterinary use.
Optimal conditions of its use should be determined by end users.

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