INSR Peptide - middle region (AAP30446)

Data Sheet
 
Sku AAP30446
Old sku AAPP01030
Price $99.00
Name INSR Peptide - middle region (AAP30446)
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Size 100 ug
Gene INSR
Alias symbols CD220, HHF5
Gene id 3643
Description of target This receptor binds insulin and has a tyrosine-protein kinase activity. Isoform Short has a higher affinity for insulin. INSR mediates the metabolic functions of insulin. INSR binding to insulin stimulates association of the receptor with downstream mediators including IRS1 and phosphatidylinositol 3'-kinase (PI3K). INSR can activate PI3K either directly by binding to the p85 regulatory subunit, or indirectly via IRS1. When present in a hybrid receptor with IGF1R, it binds IGF1.A report shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, another report shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin.After removal of the precursor signal peptide, the insulin receptor precursor is post-translationally cleaved into two chains (alpha and beta) that are covalently linked. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. Two transcript variants encoding different isoforms have been found for this gene.
Swissprot id P06213
Protein accession num NP_000199
Nucleotide accession num NM_000208
Protein size 1382 amino acids
Molecular weight 154kDa
Application IHC, WB
Partner proteins HMGA1,CSK,GRB10,IRS1,IRS1,IRS2,JAK1,PIK3R1,PIK3R1,SHC1,SOCS1,SOCS6,ACP1,ADRB2,AHSG,ARF1,ARHGAP26,CALM1,CALM3,CALM3,CAV1,CAV3,CBL,CEACAM1,CRK,CRKL,CSK,DOK1,DOK4,DOK5,ENPP1,FABP4,FRS2,GAB1,GNB2L1,GRB10,GRB14,GRB7,HRAS,IGF1R,IGF2,INS,INSR,INSRR,IRS1,IRS2,JAK1,JAK2,KHDRBS1,KRT27,MAD2L1,MAPK3,PIK3R1,PIK3R3,PLCG1,PRKCA,PRKCD,PTK2,PTPN1,PTPN11,PTPN12,PTPN2,PTPN6,PTPRC,PTPRF,RAF1,RASA1,SH2B1,SH2B2,SHC1,SMAD2,SNX1,SNX2,SNX4,SNX6,SOCS1,SOCS2,SOCS3,SOCS6,SORBS1,SRC,STAT5A,STAT5B,SYNCRIP,VAV1,VAV3,YWHAB,AHSG,CAV1,CSK,ENPP1,FRS2,GRB10,GRB14,GRB2,GRB7,Grb14,HRAS,INPPL1,INSRR,IRS1,IRS2,JAK2,KHDRBS1,MAPK1,MAPK3,PRKCD,PTPN1,PTPN11,PTPN6,RASA1,SH2B1,SHC1,SMAD2,SNX1,SNX2,SNX4,SNX6,SOCS3,SORBS1,SYNCRIP,VAV1,VAV3
Quality control The peptide is characterized by mass spectroscopy
Key reference Netzer,C., (2008) Genomics 91 (6), 503-507
Description This is a synthetic peptide designed for use in combination with anti-INSR antibody (Catalog #: AVARP08005_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
Product format Lyophilized powder
Reconstitution and storage Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles.
Lead time Domestic: within 24 hours delivery  International: 3-5 business days
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Optimal conditions of its use should be determined by end users.

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