RELA Peptide - middle region (AAP30371)

Data Sheet
 
Sku AAP30371
Old sku AAPS08809
Price $99.00
Name RELA Peptide - middle region (AAP30371)
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Size 100 ug
Gene RELA
Alias symbols MGC131774, NFKB3, p65
Gene id 5970
Description of target p65 is a subunit of the nuclear factor kappa-B, a second messenger, which activates the transcription of a number of genes in multiple tissues. The inhibitory effect of I-kappa-B upon NF-kappa-B in the cytoplasm is exerted primarily through the interaction with p65. p65 shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex. NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA, or RELB (MIM 604758) to form the NFKB complex. The p50 (NFKB1)/p65 (RELA) heterodimer is the most abundant form of NFKB. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008 or NFKBIB, MIM 604495), which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NFKB complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-1760 M62399.1 8-1767
Swissprot id Q04206
Protein accession num NP_068810
Nucleotide accession num NM_021975
Protein size 551 amino acids
Molecular weight 60kDa
Application WB
Partner proteins AES,BIRC3,CARM1,CCND1,CHEK1,CHUK,CREBBP,CREBBP,CXCL10,EGR1,EP300,EP300,FOS,IL8,ING4,JUN,NCOA3,NFKB1,NFKB1,NFKBIA,NFKBIA,NFKBIB,NFKBIB,SLC1A2,TERT,TLE1,AATF,ACTL6A,AES,AHR,AKAP8,APBA2,AR,BRCA1,BTK,BTRC,CALM1,CAMK4,CARM1,CDK9,CEBPB,CEBPD,CHEK1,CHUK,COMMD1,CREBBP,CSNK2A1,DDX1,DHX9,EGR1,EP300,ESR1,ETHE1,FAF1,FOS,FUS,GTF2B,HDAC1,HDAC2,HDAC3,HEXIM1,HMGA2,HMGB1,IKBKB,ING4,IRAK1BP1,IRF1,IRF2,IRF3,JUN,KAT2B,KPNA2,MAP2K6,MAP3K7,MAP3K8,MEN1,MST1R,MTPN,MYC,NCOA3,NCOR2,NFKB1,NFKB2,NFKBIA,NFKBIB,NFKBIE,NKRF,NKX2-1,NOTCH1,NR3C1,PARP1,PDCD11,PGR,PIAS1,PIAS3,PIN1,PML,POU2F1,PPARA,PPP1R13L,PPP2CA,PPP2R1B,PPP4C,PRKACA,PRKCZ,PRTN3,REL,RELA,RELB,REPS2,RFC1,RNF25,RPS6KA5,RXRA,SIRT1,SNIP1,SOCS1,SP1,SRF,STAT1,STAT3,STAT6,TAF1,TAF11,TAF4B,TAF6,TBK1,TBP,TERT,TNIP2,TP53BP1,TP53BP2,TRIB3,TRIP4,TSC22D3,TWIST1,UNC5CL,AES,AHR,AKAP8L,APBA2,ASCC1,ASCC2,ASCC3,BARD1,BRCA1,BTRC,CDK9,CEBPB,CEBPD,COMMD1,CREBBP,CSNK2A1,CSNK2A2,DHX9,EGR1,EP300,ETHE1,FOS,FUS,GTF2B,HDAC1,HDAC2,HDAC3,HEXIM1,HMGA2,HMGB1,Hdac1,ING4,IQGAP2,IRF2,IRF8,IRF9,ITGB3BP,JUN,KDM2A,KPNA2,MAP3K8,MEN1,MTPN,MYC,NCF1,NCOA6,NCOR2,NFKB1,NFKB2,NFKBIA,NFKBIB,NFKBIE,NKRF,NKX2-1,NOTCH1,NR3C1,NSD1,PARP1,PDLIM2,PGR,PIAS3,PML,POU2F1,PPARA,PPP1R13L,PPP2CA,PPP2CB,PPP4C,PRKCZ,REL,RELA,RELB,RFC1,RNF25,RXRA,SOCS1,SP1,SRF,STAT3,TAF1,TAF11,TAF4B,TAF6,TBK1,TBP,TERT,TLE1,TNIP2,TRIB3,TWIST1,UBC,UNC5CL
Quality control The peptide is characterized by mass spectroscopy
Key reference Wittwer,T. (2008) Biochem. Biophys. Res. Commun. 371 (2), 294-297
Description This is a synthetic peptide designed for use in combination with anti-RELA antibody (Catalog #: ARP30371_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
Product format Lyophilized powder
Reconstitution and storage Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles.
Lead time Domestic: within 24 hours delivery  International: 3-5 business days
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