| Product Number |
P100807_P050 |
| Product Page |
www.avivasysbio.com/etv6-antibody-c-terminal-region-p100807-p050.html |
| Name |
ETV6 Antibody - C-terminal region (P100807_P050) |
| Protein Size (# AA) |
452 amino acids |
| Molecular Weight |
53kDa |
| NCBI Gene Id |
2120 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
0.5 mg/ml |
| Gene Full Name |
Ets variant 6 |
| Description |
|
| Alias Symbols |
TEL, THC5, TEL/ABL |
| Peptide Sequence |
Synthetic peptide located within the following region: VSVSPPEEHAMPIGRIADCRLLWDYVYQLLSDSRYENFIRWEDKESKIFR |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reference |
Schick,N., et al., (2004) J.Biol.Chem.279(37),38787-38796 |
| Description of Target |
ETV6 (ETS-related protein Tel1, ETS translocation variant 6 , Tel) is an ETS family transcription factor. This protein contains two functional domains: a N-terminal pointed (PNT) domain that is involved in the protein-protein interactions with itself and other proteins, and a C-terminal DNA-binding domain. Gene knockout studies in mice suggest that it is required for hematopoiesis and maintenance of the developing vascular network. This gene is known to be involved in a large number of chromosomal rearrangements associated with leukemia and congenital fibrosarcoma.This gene encodes an ETS family transcription factor. The product of this gene contains two functional domains: a N-terminal pointed (PNT) domain that is involved in the protein-protein interactions with itself and other proteins, and a C-terminal DNA-binding domain. Gene knockout studies in mice suggest that it is required for hematopoiesis and maintenance of the developing vascular network. This gene is known to be involved in a large number of chromosomal rearrangements associated with leukemia and congenital fibrosarcoma. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. |
| Protein Interactions |
AP1M1; WDYHV1; UBC; SUMO1; NEDD8; ETV6; SUMO2; PIN1; HDAC6; SOX2; TRAF3; SOCS3; SOCS1; PDGFRB; ELAVL1; UBE2I; NCOR1; SIN3A; HDAC3; L3MBTL1; SMURF1; HDAC9; KAT5; FLI1; IRF8; SKP1; FBXL6; GAB2; GRB2; CRKL; ACTA1; |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-ETV6 (P100807_P050) antibody |
| Blocking Peptide |
For anti-ETV6 (P100807_P050) antibody is Catalog # AAP31149 (Previous Catalog # AAPS19405) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the C terminal region of human ETV6 |
| Uniprot ID |
P41212 |
| Protein Name |
Transcription factor ETV6 |
| Protein Accession # |
NP_001978 |
| Purification |
Affinity Purified |
| Nucleotide Accession # |
NM_001987 |
| Tested Species Reactivity |
Human, Mouse |
| Gene Symbol |
ETV6 |
| Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish |
| Application |
IHC, WB |
| Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 100%; Guinea Pig: 92%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 92% |
| Image 1 | Mouse Small Intestine
 | Host: Mouse
Target Name: ETV6
Sample Tissue: Mouse Small Intestine
Antibody Dilution: 1ug/ml |
|
| Image 2 | Human Jurkat
 | WB Suggested Anti-ETV6 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:1562500
Positive Control: Jurkat cell lysate |
|
| Image 3 | Human Stomach
 | Human Stomach |
|
| Image 4 | Mouse Spleen, Mouse Brain
 | Host: Rabbit
Target: ETV6
Positive control (+): Mouse Spleen (M-SP)
Negative control (-): Mouse Brain (M-BR)
Antibody concentration: 1ug/ml |
|
