| Product Number |
OACA04097 |
| Product Page |
www.avivasysbio.com/pick1-antibody-oaca04097.html |
| Name |
PICK1 Antibody (OACA04097) |
| Isotype |
IgG |
| Conjugation |
Unconjugated |
| NCBI Gene Id |
9463 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Gene Full Name |
protein interacting with PRKCA 1 |
| Alias Symbols |
PICK;PRKCA-binding protein;PRKCABP;protein interacting with C kinase 1;protein kinase C-alpha-binding protein. |
| Product Format |
Liquid |
| Reference |
[1]"Reevaluating human gene annotation: a second-generation analysis of chromosome 22."Collins J.E., Goward M.E., Cole C.G., Smink L.J., Huckle E.J., Knowles S., Bye J.M., Beare D.M., Dunham I.Genome Res. 13:27-36(2003). [2]"A genome annotation-driven approach to cloning the human ORFeome." Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A., Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J., Beare D.M., Dunham I. Genome Biol. 5:R84.1-R84.11(2004). [3]"he status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."The MGC Project TeamGenome Res. 14:2121-2127(2004). |
| Description of Target |
Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competetive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function. |
| Reconstitution and Storage |
-20°C or -80°C |
| Datasheets/Manuals |
Printable datasheet for PICK1 Antibody (OACA04097) (OACA04097) |
| Immunogen |
Recombinant Human PRKCA-binding protein (1-200AA) |
| Formulation |
50% Glycerol, 0.01M PBS, PH 7.4 |
| Uniprot ID |
Q9NRD5 |
| Protein Name |
PRKCA-binding protein |
| Protein Accession # |
NP_001034672 |
| Purification |
Protein G Purified |
| Nucleotide Accession # |
NM_001039583 |
| Preservative |
0.03% Proclin 300 |
| Gene Symbol |
PICK1 |
| Predicted Species Reactivity |
Human|Mouse |
| Application |
Enzyme-linked immunosorbent assay|Immunohistochemistry|Western blot |
| Image 1 | Mouse brain tissue
 | Western blot
All lanes: PICK1 antibody at 2ug/ml+mouse brain tissue
Secondary
Goat polyclonal to rabbit IgG at 1/1,0000 dilution
Predicted band size: 47,40 kDa
Observed band size: 47 kDa
|
| | Image 2 | Human breast cancer
 | Immunohistochemistry of paraffin-embedded human breast cancer at dilution 1:100 |
| | Image 3 | Human rectum tissue
 | Immunohistochemistry of paraffin-embedded human rectum tissue at dilution 1:100 |
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