| Product Number |
OABI00013 |
| Product Page |
www.avivasysbio.com/vegfr2-antibody-oabi00013.html |
| Name |
VEGFR2 Antibody (OABI00013) |
| Molecular Weight |
151 kDa |
| Isotype |
IgG |
| Conjugation |
Unconjugated |
| NCBI Gene Id |
3791 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Purity |
Polyclonal antibodies are purified by peptide affinity chromatography |
| Concentration |
100 ug (in 200 ul): 0.5 mg/ml. 200 ug (in 400 ul): 0.5 mg/ml |
| Description |
In recent decades, a variety of signaling molecules, such as VEGF-VEGFRs, ephrin-Eph receptors, angiopoietin-Tie, and the Delta-Notch system, have been identified as playing important roles in angiogenesis. Among these, vascular endothelial growth factors (VEGFs) and receptors (VEGFRs) regulate both vasculogenesis, the development of blood vessels from precursor cells during early embryogenesis, and angiogenesis, the formation of blood vessels from pre-existing vessels at a later stage3. VEGFR-1 and VEGFR-2 play major roles in physiological as well as pathological angiogenesis, including tumor angiogenesis. VEGFR-2, the major signal transducer for angiogenesis, preferentially utilizes the PLC gamma-PKC-MAPK pathway for signaling. |
| Alias Symbols |
FLK1, CD309, VEGFR, VEGFR2 |
| Product Format |
Liquid. 10 mM PBS, 0.02% sodium azide |
| Description of Target |
In recent decades, a variety of signaling molecules, such as VEGF-VEGFRs, ephrin-Eph receptors, angiopoietin-Tie, and the Delta-Notch system, have been identified as playing important roles in angiogenesis. Among these, vascular endothelial growth factors (VEGFs) and receptors (VEGFRs) regulate both vasculogenesis, the development of blood vessels from precursor cells during early embryogenesis, and angiogenesis, the formation of blood vessels from pre-existing vessels at a later stage3. VEGFR-1 and VEGFR-2 play major roles in physiological as well as pathological angiogenesis, including tumor angiogenesis.VEGFR-2, the major signal transducer for angiogenesis, preferentially utilizes the PLC gamma-PKC-MAPK pathway for signaling. |
| Reconstitution and Storage |
Store at 4C for up to two weeks. For long term storage, aliquot and store at -20C, avoid freeze/thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for OABI00013 |
| Application Info |
WB: 2 ug/ml, IHC-P:1:200, IF/ICC: 1:200 |
| Immunogen |
KLH conjugated synthetic peptide derived from human VEGFR2. Please contact us for the exact immunogen sequence. |
| Uniprot ID |
P35968, P35918, O08775 |
| Protein Accession # |
NP_002244.11 |
| Purification |
Purified by peptide affinity chromatography |
| Nucleotide Accession # |
NM_002253.21 |
| Tested Species Reactivity |
Canine, Human, Mouse, Porcine, Rat |
| Gene Symbol |
VEGFR2 |
| Application |
ELISA, ICC, IF, IHC-P, WB |
| Image 1 | Mouse lymph node tissue
 | Immunofluorescence analysis of mouse lymph node tissue using anti-VEGFR2 (dilution of primary antibody - 1:200) |
|
| Image 2 | Mouse lymph node tissue
 | Immunofluorescence image of mouse lymph node tissue using anti-VEGFR2 (dilution at 1:200) |
|
| Image 3 | Breast cancer 3 (lane 1), breast cancer 2 (lane 2), breast cancer 1 (lane 3)
 | WB analysis of breast cancer 3 (lane 1), breast cancer 2 (lane 2), breast cancer 1 (lane 3) using VEGFR2 (dilution of primary antibody - 2 ug/ml) |
|
| Image 4 | Human breast cancer tissue
 | Western blot analysis of human breast cancer tissue using VEGFR2 antibody (Dilution at 2 ug/ml) |
|
