| Product Number |
OABF00360 |
| Product Page |
www.avivasysbio.com/ace2-antibody-oabf00360.html |
| Name |
ACE2 Antibody (OABF00360) |
| Isotype |
IgG |
| Conjugation |
Unconjugated |
| NCBI Gene Id |
59272 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
1 ug/ul |
| Gene Full Name |
angiotensin converting enzyme 2 |
| Alias Symbols |
ACEH;ACE-related carboxypeptidase;angiotensin I converting enzyme (peptidyl-dipeptidase A) 2;angiotensin I converting enzyme 2;angiotensin-converting enzyme 2;angiotensin-converting enzyme homolog;angiotensin-converting enzyme-related carboxypeptidase;metalloprotease MPROT15;peptidyl-dipeptidase A;truncated angiotensin converting enzyme 2. |
| Product Format |
Liquid Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. |
| Description of Target |
Essential counter-regulatory carboxypeptidase of the renin-angiotensin hormone system that is a critical regulator of blood volume, systemic vascular resistance, and thus cardiovascular homeostasis (PubMed:27217402). Converts angiotensin I to angiotensin 1-9, a nine-amino acid peptide with anti-hypertrophic effects in cardiomyocytes, and angiotensin II to angiotensin 1-7, which then acts as a beneficial vasodilator and anti-proliferation agent, counterbalancing the actions of the vasoconstrictor angiotensin II (PubMed:10969042, PubMed:10924499, PubMed:11815627, PubMed:19021774, PubMed:14504186). Also removes the C-terminal residue from three other vasoactive peptides, neurotensin, kinetensin, and des-Arg bradykinin, but is not active on bradykinin (PubMed:10969042, PubMed:11815627). Also cleaves other biological peptides, such as apelins (apelin-13, [Pyr1]apelin-13, apelin-17, apelin-36), casomorphins (beta-casomorphin-7, neocasomorphin) and dynorphin A with high efficiency (PubMed:11815627, PubMed:27217402, PubMed:28293165). In addition, ACE2 C-terminus is homologous to collectrin and is responsible for the trafficking of the neutral amino acid transporter SL6A19 to the plasma membrane of gut epithelial cells via direct interaction, regulating its expression on the cell surface and its catalytic activity (PubMed:18424768, PubMed:19185582). |
| Reconstitution and Storage |
-20°C |
| Datasheets/Manuals |
Printable datasheet for ACE2 Antibody (OABF00360) |
| Application Info |
WB: 1:300~1000
FC: 1:20~100
IHC-P: 1:200~400
IHC-F: 1:100~500 |
| Immunogen |
KLH conjugated synthetic peptide derived from human ACE2 |
| Uniprot ID |
Q9BYF1 |
| Protein Name |
Angiotensin-converting enzyme 2 |
| Purification |
Protein A Purified |
| Gene Symbol |
ACE2 |
| Predicted Species Reactivity |
Bat|Dog|Human|Mouse|Porcine|Rat|Sheep |
| Application |
Enzyme-linked immunosorbent assay|Flow cytometry|Immunocytochemistry|Immunofluorescence|Immunohistochemistry-Frozen|Immunohistochemistry-Paraffin|Western blot |
| Image 1 | |
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