MYOC Antibody (OAAJ06957)

• Product Number: OAAJ06957
• Name: MYOC Antibody (OAAJ06957)
• Molecular Weight: 57 kDa
• NCBI Gene Id: 4653
• Host: Rabbit
• Clonality: Polyclonal
• Concentration: 1 mg/mL
• Alias Symbols: GPOA, JOAG, TIGR, GLC1A, JOAG1
• Product Format: Liquid
• Description of Target: Secreted glycoprotein regulating the activation of different signaling pathways in adjacent cells to control different processes including cell adhesion, cell-matrix adhesion, cytoskeleton organization and cell migration. Promotes substrate adhesion, spreading and formation of focal contacts. Negatively regulates cell-matrix adhesion and stress fiber assembly through Rho protein signal transduction. Modulates the organization of actin cytoskeleton by stimulating the formation of stress fibers through interactions with components of Wnt signaling pathways. Promotes cell migration through activation of PTK2 and the downstream phosphatidylinositol 3-kinase signaling. Plays a role in bone formation and promotes osteoblast differentiation in a dose-dependent manner through mitogen-activated protein kinase signaling. Mediates myelination in the peripheral nervous system through ERBB2/ERBB3 signaling. Plays a role as a regulator of muscle hypertrophy through the components of dystrophin-associated protein complex. Involved in positive regulation of mitochondrial depolarization. Plays a role in neurite outgrowth. May participate in the obstruction of fluid outflow in the trabecular meshwork.
• Reconstitution and Storage: Store at +4C. For long term storage, aliquot and store at -20C. Avoid freeze/thaw cycles.
• Immunogen: Recombinant proteinof human MYOC
• Uniprot ID: Q99972
• Protein Name: Myocilin
• Protein Accession #: NP_000252
• Purification: Immunogen affinity chromatography
• Nucleotide Accession #: NM_000261
• Gene Symbol: MYOC
• Predicted Species Reactivity: Human, Mouse, Rat
• Application: WB, IHC
• Image 1: human heart tissue
  
  Western blot analysis of extracts of human heart tissue, using MYOC antibody.