| Product Number |
OAAF00734 |
| Product Page |
www.avivasysbio.com/fos-antibody-oaaf00734.html |
| Name |
FOS Antibody (OAAF00734) |
| Molecular Weight |
40 kDa |
| Isotype |
IgG |
| NCBI Gene Id |
2353 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Gene Full Name |
Fos proto-oncogene, AP-1 transcription factor subunit |
| Alias Symbols |
activator protein 1;AP-1;cellular oncogene c-fos;Cellular oncogene fos;C-FOS;FBJ murine osteosarcoma viral (v-fos) oncogene homolog (oncogene FOS);FBJ murine osteosarcoma viral oncogene homolog;Fos proto-oncogene, AP-1 trancription factor subunit;G0/G1 switch regulatory protein 7;p55;proto-oncogene c-Fos. |
| Product Format |
Liquid. PBS (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Reference |
van Straaten F., Proc. Natl. Acad. Sci. U.S.A. 80:3183-3187(1983).
Hai T., Genes Dev. 3:2083-2090(1989).
Heilig R., Nature 421:601-607(2003). |
| Description of Target |
Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum. |
| Reconstitution and Storage |
-20°C |
| Datasheets/Manuals |
Printable datasheet for FOS Antibody (OAAF00734) |
| Specificity |
FOS antibody detects endogenous levels of total FOS protein. |
| Application Info |
IHC 1:50~100
ELISA 1:1000
|
| Immunogen |
The antiserum was produced against synthesized peptide derived from human Fos. |
| Dilution |
The optimal working dilution should be determined by the end user. |
| Intended Use |
The product is for research use only, not for use in diagnostic or therapeutic procedures. |
| Uniprot ID |
P01100 |
| Protein Name |
Proto-oncogene c-Fos |
| Protein Accession # |
NP_005243.1 |
| Purification |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Gene Symbol |
FOS |
| Predicted Species Reactivity |
Human|Mouse|Rat |
| Application |
Enzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry|Immunohistochemistry-Paraffin|Western blot |
| Image 1 | human breast carcinoma tissue
 | Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using Fos Antibody. The picture on the right is blocked with the synthesized peptide. |
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