CTDSP2 Antibody - N-terminal region (OAAB17631)

• Product Number: OAAB17631
• Name: CTDSP2 Antibody - N-terminal region (OAAB17631)
• Molecular Weight: 31 kDa
• Isotype: Rabbit Ig
• NCBI Gene Id: 10106
• Host: Rabbit
• Clonality: Polyclonal
• Concentration: 2 mg/ml
• Alias Symbols: OS4, PSR2, SCP2
• Product Format: Liquid. PBS with 0.09% (W/V) sodium azide.
• Description of Target: CTDSP2 is one of several small CTD phosphatases (SCP). It has been proposed that SCP activity is an evolutionarily conserved transcriptional regulator that acts globally to silence neuronal genes. In addition, expression of phosphatase CTDSP2 mRNA isenhanced in several cancer cell lines with amplification of the CTDSP2 and CDK4 genes, and CTDSP2 coamplifies with CDK4 in some primary sarcomas. CTDSP2 may contribute to the development of a subset of sarcomas.
• Reconstitution and Storage: Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
• Additional Information: Cellular Location: Nucleus
  Tissue Location: Expression is restricted to non-neuronal tissues. Highest expression in pancreas and lowest in liver
• Application Info: WB: 1:1000
  IHC-P: 1:50~100
• Immunogen: This CTDSP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 12-42 amino acids from the N-terminal region of human CTDSP2.
• Intended Use: For research use only and not for use in diagnostic or therapeutic procedures.
• Uniprot ID: O14595
• Protein Name: Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2
• Protein Accession #: NP_005721.3
• Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
• Gene Symbol: CTDSP2
• Predicted Species Reactivity: Human, Mouse
• Application: WB, IHC-P
• Image 1: Human breast carcinoma
  
  Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with CTDSP2 Antibody (N-term) (Cat.# OAAB17631), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
• Image 2: breast carcinoma
  
  Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
• Image 3: Mouse Lung
  
  Western blot analysis of anti-CTDSP2 Antibody (N-term) (Cat.# OAAB17631) in mouse lung tissue lysates (35ug/lane). CTDSP2(arrow) was detected using the purified Pab (1:60 dilution).
• Image 4: HepG2
  
  Western blot analysis of anti-CTDSP2 Antibody (N-term) (Cat.# OAAB17631) in HepG2 cell line lysates (35ug/lane). hCTDSP2-S27(arrow) was detected using the purified Pab (1:60dilution).