| Product Number |
AVARP01012_P050 |
| Product Page |
www.avivasysbio.com/fadd-antibody-c-terminal-region-avarp01012-p050.html |
| Name |
FADD Antibody - C-terminal region (AVARP01012_P050) |
| Protein Size (# AA) |
208 amino acids |
| Molecular Weight |
23kDa |
| NCBI Gene Id |
8772 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
0.5 mg/ml |
| Gene Full Name |
Fas (TNFRSF6)-associated via death domain |
| Alias Symbols |
GIG3, MORT1 |
| Peptide Sequence |
Synthetic peptide located within the following region: AHLVGALRSCQMNLVADLVQEVQQARDLQNRSGAMSPMSWNSDASTSEAS |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reference |
Thomas,L.R., et al., (2004) J. Biol. Chem. 279 (31), 32780-32785 |
| Description of Target |
The protein encoded by FADD is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. |
| Protein Interactions |
CFLAR; CASP10; CASP8; ATG5; ATG12; TNF; TRADD; UBC; RIPK1; FAS; TNFSF10; SPOP; TNFRSF1A; MYD88; TNFRSF10A; TNFRSF10B; MKRN1; RIPK3; CUL3; TRAF2; PARK7; FASLG; LRRK2; IKBKG; BMX; FAF1; EDAR; DAPK1; CLIP3; DAXX; TNFAIP3; MAVS; KHDRBS1; TAB1; EZR; TRIM21; IR |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-FADD (AVARP01012_P050) antibody |
| Blocking Peptide |
For anti-FADD (AVARP01012_P050) antibody is Catalog # AAP30341 (Previous Catalog # AAPP00722) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the C terminal region of human FADD |
| Uniprot ID |
Q13158 |
| Protein Name |
Protein FADD |
| Protein Accession # |
NP_003815 |
| Purification |
Affinity Purified |
| Nucleotide Accession # |
NM_003824 |
| Tested Species Reactivity |
Human |
| Gene Symbol |
FADD |
| Predicted Species Reactivity |
Human |
| Application |
IHC, WB |
| Predicted Homology Based on Immunogen Sequence |
Human: 100% |
| Image 1 | Human kidney
 | Human kidney |
| | Image 2 | Human Thymus
 | WB Suggested Anti-FADD Antibody Titration: 0.2-1 ug/ml
Positive Control: Human Thymus |
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