| Product Number |
AVARP00021_T100-FITC |
| Product Page |
www.avivasysbio.com/casp3-antibody-n-terminal-region-fitc-avarp00021-t100-fitc.html |
| Name |
CASP3 Antibody - N-terminal region : FITC (AVARP00021_T100-FITC) |
| Protein Size (# AA) |
277 amino acids |
| Molecular Weight |
32kDa |
| Conjugation |
FITC: Fluorescein Isothiocyanate |
| NCBI Gene Id |
836 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
0.5 mg/ml |
| Gene Full Name |
Caspase 3, apoptosis-related cysteine peptidase |
| Alias Symbols |
CPP32, SCA-1, CPP32B |
| Peptide Sequence |
Synthetic peptide located within the following region: MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIII |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer. |
| Reference |
Selvakumar,P., et al., (2006) FEBS Lett. 580 (8), 2021-2026 |
| Description of Target |
CASP3 is a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein. |
| Protein Interactions |
BAX; PARP1; PTGES3; XIAP; CRYAB; BIRC7; UBC; MDM2; Gzmb; VIM; STAT1; SPTAN1; ROCK1; GSN; DFFA; CASP9; CASP7; CASP6; CASP2; BID; ARHGDIA; TNFSF10; PLA2G4B; CDKN1A; RB1; PRKDC; GLRX; GATA1; SOCS5; YWHAG; MAPK9; MAPK8; SP1; PKN1; CASP8; BIRC3; BIRC2; ZBTB16; |
| Reconstitution and Storage |
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil). Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding. |
| Datasheets/Manuals |
Printable datasheet for anti-CASP3 (AVARP00021_T100-FITC) antibody |
| Blocking Peptide |
For anti-CASP3 (AVARP00021_T100-FITC) antibody is Catalog # AAP30492 (Previous Catalog # AAPP01128) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the N terminal region of human CASP3 |
| Uniprot ID |
P42574 |
| Protein Name |
Caspase-3 |
| Protein Accession # |
NP_004337 |
| Nucleotide Accession # |
NM_004346 |
| Gene Symbol |
CASP3 |
| Predicted Species Reactivity |
Human, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit |
| Application |
IHC, WB |
| Predicted Homology Based on Immunogen Sequence |
Cow: 84%; Dog: 84%; Guinea Pig: 84%; Horse: 92%; Human: 100%; Pig: 92%; Rabbit: 84%; Rat: 84% |
| Image 1 | |
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