| Product Number |
ARP31212_P050 |
| Product Page |
www.avivasysbio.com/mitf-antibody-middle-region-arp31212-p050.html |
| Name |
MITF Antibody - middle region (ARP31212_P050) |
| Protein Size (# AA) |
357 amino acids |
| Molecular Weight |
39kDa |
| NCBI Gene Id |
4286 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
0.5 mg/ml |
| Gene Full Name |
microphthalmia-associated transcription factor |
| Alias Symbols |
MI, WS2, CMM8, WS2A, COMMAD, bHLHe32 |
| Peptide Sequence |
Synthetic peptide located within the following region: NSNCEKEGFYKFEEQNRAESECPGMNTHSRASCMQMDDVIDDIISLESSY |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Description of Target |
MITF is a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. It regulates the differentiation and development of melanocytes retinal pigment epithelium and is also responsible for pigment cell-specific transcription of the melanogenesis enzyme genes. Heterozygous mutations in the this gene cause auditory-pigmentary syndromes, such as Waardenburg syndrome type 2 and Tietz syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. |
| Protein Interactions |
EBP; STUB1; HK3; EPAS1; LEF1; APP; HINT1; ELAVL1; CDK2; SUMO2; PSMD14; MARK3; PIAS3; PIAS2; PIAS1; SUMO1; UBE2I; PAX3; OTX2; PAX6; PATZ1; GSK3B; TFEC; EP300; RPS6KA1; TFEB; MAPK14; TFE3; MAPK1; SPI1; FOS; CTNNB1; CDKN1A; RB1; |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-MITF (ARP31212_P050) antibody |
| Blocking Peptide |
For anti-MITF (ARP31212_P050) antibody is Catalog # AAP31212 |
| Immunogen |
The immunogen is a synthetic peptide directed towards the middle region of Human MITF |
| Uniprot ID |
O75030-11 |
| Protein Name |
Microphthalmia-associated transcription factor |
| Publications |
Schartl, M. et al. A mutated EGFR is sufficient to induce malignant melanoma with genetic background-dependent histopathologies. J. Invest. Dermatol. 130, 249-58 (2010). 19609310 |
| Protein Accession # |
NP_937821 |
| Purification |
Affinity Purified |
| Nucleotide Accession # |
NM_198178 |
| Tested Species Reactivity |
Human |
| Gene Symbol |
MITF |
| Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Sheep |
| Application |
WB |
| Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 92%; Rabbit: 100%; Rat: 100%; Sheep: 100% |
| Image 1 | Human Esophagus Tumor
 | Host: Rabbit
Target Name: MITF
Sample Type: Esophagus Tumor lysates
Antibody Dilution: 1.0ug/ml |
|
