| Product Number |
ARP31088_P050 |
| Product Page |
www.avivasysbio.com/esr1-antibody-c-terminal-region-arp31088-p050.html |
| Name |
ESR1 Antibody - C-terminal region (ARP31088_P050) |
| Protein Size (# AA) |
595 amino acids |
| Molecular Weight |
66kDa |
| NCBI Gene Id |
2099 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
0.5 mg/ml |
| Gene Full Name |
Estrogen receptor 1 |
| Alias Symbols |
ER, ESR, Era, ESRA, ESTRR, NR3A1 |
| Peptide Sequence |
Synthetic peptide located within the following region: AHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Description of Target |
ESR1 is an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative splicing results in several transcript variants, which differ in their 5' UTRs and use different promoters. |
| Protein Interactions |
SRC; DDX5; POLR2C; POLR2B; POLR2A; MSH2; TTC5; KAT5; NCOA2; BRCA1; MED24; UBC; PSMB9; MED1; POLR2L; POLR2K; POLR2J; POLR2I; POLR2H; POLR2G; POLR2F; POLR2E; POLR2D; ASCC1; TRRAP; PHB2; NCOR1; NCOA1; PIK3CA; IGF1R; HDAC1; NSD1; WIPI1; ESR1; ZNF131; RANBP9; |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-ESR1 (ARP31088_P050) antibody |
| Blocking Peptide |
For anti-ESR1 (ARP31088_P050) antibody is Catalog # AAP31088 |
| Immunogen |
The immunogen is a synthetic peptide directed towards the C terminal region of human ESR1 |
| Uniprot ID |
P03372 |
| Protein Name |
Estrogen receptor |
| Protein Accession # |
NP_000116 |
| Purification |
Affinity Purified |
| Nucleotide Accession # |
NM_000125 |
| Tested Species Reactivity |
Human |
| Gene Symbol |
ESR1 |
| Predicted Species Reactivity |
Human |
| Application |
WB |
| Predicted Homology Based on Immunogen Sequence |
Human: 100% |
| Image 1 | Human ACHN
 | WB Suggested Anti-ESR1 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:12500
Positive Control: ACHN cell lysate |
| | Image 2 | Human Fetal Muscle
 | Host: Rabbit
Target Name: ESR1
Sample Type: Human Fetal Muscle
Antibody Dilution: 1.0ug/ml |
| | Image 3 | Human Adult Placenta
 | Host: Rabbit
Target Name: ESR1
Sample Type: Human Adult Placenta
Antibody Dilution: 1.0ug/ml |
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