| Product Number |
ARP54671_P050 |
| Product Page |
www.avivasysbio.com/kpna1-antibody-n-terminal-region-arp54671-p050.html |
| Name |
KPNA1 Antibody - N-terminal region (ARP54671_P050) |
| Protein Size (# AA) |
538 amino acids |
| Molecular Weight |
60kDa |
| Subunit |
alpha-1 |
| NCBI Gene Id |
3836 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
0.5 mg/ml |
| Gene Full Name |
Karyopherin alpha 1 (importin alpha 5) |
| Alias Symbols |
RCH2, SRP1, IPOA5, NPI-1 |
| Peptide Sequence |
Synthetic peptide located within the following region: NMEMAPGGVITSDMIEMIFSKSPEQQLSATQKFRKLLSKEPNPPIDEVIS |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reference |
Theodore,M., (2008) J. Biol. Chem. 283 (14), 8984-8994 |
| Description of Target |
Recombination activating proteins RAG1 and RAG2 regulate and mediate V(D)J recombination, the process by which genes for immunoglobulins and T-cell receptors are generated. Several other ubiquitously expressed proteins are thought to be recruited in the recombination process. Among these are the genes affected in severe combined immune deficiency and genes involved in ds-DNA break repair. KPNA1 interacts with RAG1 and may play a role in V(D)J recombination.Recombination activating proteins RAG1 and RAG2 regulate and mediate V(D)J recombination, the process by which genes for immunoglobulins and T-cell receptors are generated. Several other ubiquitously expressed proteins are thought to be recruited in the recombination process. Among these are the genes affected in severe combined immune deficiency and genes involved in ds-DNA break repair. The protein encoded by this gene interacts with RAG1 and may play a role in V(D)J recombination. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. |
| Protein Interactions |
UBC; TAF9; CLK4; NUP50; ANP32B; XRN2; rev; TRMT61A; KCTD12; NPM1; GABPA; DCAF6; LIMCH1; HECW2; CLK3; HDAC2; HDAC1; GOPC; HDAC6; CRADD; LMO4; BCAR3; FOSL1; SKP2; ORC4; IL1RAP; AICDA; TP53BP1; KPNB1; RAG1; NOSIP; DCAF8; ANP32A; CAND1; COPS5; CUL1; CUL3; CUL |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-KPNA1 (ARP54671_P050) antibody |
| Blocking Peptide |
For anti-KPNA1 (ARP54671_P050) antibody is Catalog # AAP54671 (Previous Catalog # AAPP31462) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the N terminal region of human KPNA1 |
| Uniprot ID |
P52294 |
| Protein Name |
Importin subunit alpha-1 |
| Protein Accession # |
NP_002255 |
| Purification |
Affinity Purified |
| Nucleotide Accession # |
NM_002264 |
| Tested Species Reactivity |
Human, Mouse |
| Gene Symbol |
KPNA1 |
| Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Yeast, Zebrafish |
| Application |
WB |
| Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Yeast: 77%; Zebrafish: 85% |
| Image 1 | Human HepG2
 | WB Suggested Anti-KPNA1 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:312500
Positive Control: HepG2 cell lysate |
|
| Image 2 | Human Fetal Brain
 | Host: Rabbit
Target Name: KPNA1
Sample Type: Human Fetal Brain
Antibody Dilution: 1.0ug/ml |
|
| Image 3 | Human Jurkat
 | Host: Rabbit
Target Name: KPNA1
Sample Type: Jurkat
Antibody Dilution: 1.0ug/ml |
|
| Image 4 | Mouse Testis
 | Host: Mouse
Target Name: KPNA1
Sample Tissue: Mouse Testis
Antibody Dilution: 1ug/ml |
|
