| Product Number |
ARP46040_T100 |
| Product Page |
www.avivasysbio.com/cenpa-antibody-n-terminal-region-arp46040-t100.html |
| Name |
CENPA Antibody - N-terminal region (ARP46040_T100) |
| Protein Size (# AA) |
140 amino acids |
| Molecular Weight |
16kDa |
| NCBI Gene Id |
1058 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
1.0 mg/ml |
| Gene Full Name |
Centromere protein A |
| Alias Symbols |
CenH3, CENP-A |
| Peptide Sequence |
Synthetic peptide located within the following region: MGPRRRSRKPEAPRRRSPSPTPTPGPSRRGPSLGASSHQHSRRRQGWLKE |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reference |
Black,B.E., (2004) Nature 430 (6999), 578-582 |
| Description of Target |
Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. CENPA is a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. CENPA is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle.Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. CENPA encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. CENPA is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle. |
| Protein Interactions |
HIST1H4A; HIST1H2AB; H3F3A; HIST1H2BB; DIAPH3; DIAPH1; NPM1; HIST1H1A; H2AFZ; H2AFX; CENPC; CENPB; HIST3H2BB; HIST4H4; CENPT; CENPU; CENPM; CENPH; CENPN; HJURP; SUPT16H; H2AFY; AURKB; HIST1H3E; HIST2H2AC; SSRP1; RUVBL1; XRCC5; PRKDC; HNRNPU; EIF4A1; DDX5; |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-CENPA (ARP46040_T100) antibody |
| Additional Information |
IHC Information: Jurkat cell lysate. Antibody concentration: 1.25 ug/ml. Gel concentration: 15%. |
| Blocking Peptide |
For anti-CENPA (ARP46040_T100) antibody is Catalog # AAP46040 (Previous Catalog # AAPP26881) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the N terminal region of human CENPA |
| Uniprot ID |
P49450 |
| Protein Name |
Histone H3-like centromeric protein A |
| Sample Type Confirmation |
CENPA is strongly supported by BioGPS gene expression data to be expressed in Jurkat |
| Protein Accession # |
NP_001800 |
| Purification |
Protein A purified |
| Nucleotide Accession # |
NM_001809 |
| Tested Species Reactivity |
Human |
| Gene Symbol |
CENPA |
| Predicted Species Reactivity |
Human, Mouse, Rat |
| Application |
IHC, WB |
| Predicted Homology Based on Immunogen Sequence |
Human: 100%; Mouse: 90%; Rat: 90% |
| Image 1 | Human Jurkat
 | WB Suggested Anti-CENPA Antibody Titration: 1.25ug/ml
Positive Control: Jurkat cell lysateCENPA is strongly supported by BioGPS gene expression data to be expressed in Human Jurkat cells |
| | Image 2 | Human Skin
 | Human Skin |
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