| Product Number |
ARP36679_T100 |
| Product Page |
www.avivasysbio.com/runx2-antibody-middle-region-arp36679-t100.html |
| Name |
RUNX2 Antibody - middle region (ARP36679_T100) |
| Protein Size (# AA) |
589 amino acids |
| Molecular Weight |
64kDa |
| NCBI Gene Id |
860 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
1.0 mg/ml |
| Gene Full Name |
Runt-related transcription factor 2 |
| Alias Symbols |
CCD, AML3, CCD1, CLCD, OSF2, CBFA1, OSF-2, PEA2aA, PEBP2aA, CBF-alpha-1 |
| Peptide Sequence |
Synthetic peptide located within the following region: YHRAIKVTVDGPREPRRHRQKLDDSKPSLFSDRLSDRLSDLGRIPHPSMR |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reference |
Ducy,P., et al., (1997) Cell. 89 (5), 747-54 |
| Description of Target |
The RUNX2 gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis, acting as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). |
| Protein Interactions |
HDAC7; HDAC6; TP53; UBC; RB1; PML; HIF1A; SMURF1; SMAD1; SMURF2; HIVEP3; WWP1; FHL2; UBTF; SUV39H1; HDAC1; STAT3; SMAD3; RBM14; SOX9; NR0B2; EP300; HDAC5; HDAC4; HDAC3; CREBBP; XRCC5; HES1; XRCC6; BMPR1A; KAT2B; TLE1; YAP1; KAT6B; TAF1A; AXIN1; SMAD6; MAP |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-RUNX2 (ARP36679_T100) antibody |
| Blocking Peptide |
For anti-RUNX2 (ARP36679_T100) antibody is Catalog # AAP36679 (Previous Catalog # AAPP08106) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the middle region of human RUNX2 |
| Uniprot ID |
Q13950 |
| Protein Name |
Runt-related transcription factor 2 Ensembl ENSP00000319087 EMBL CAI19641.1 |
| Purification |
Protein A purified |
| Tested Species Reactivity |
Human |
| Gene Symbol |
RUNX2 |
| Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish |
| Application |
WB |
| Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 80% |
| Image 1 | Human HepG2
 | WB Suggested Anti-RUNX2 Antibody Titration: 1.25ug/ml
ELISA Titer: 1:312500
Positive Control: HepG2 cell lysate |
|
