| Product Number |
ARP36650_T100 |
| Product Page |
www.avivasysbio.com/mcm6-antibody-c-terminal-region-arp36650-t100.html |
| Name |
MCM6 Antibody - C-terminal region (ARP36650_T100) |
| Protein Size (# AA) |
821 amino acids |
| Molecular Weight |
90kDa |
| NCBI Gene Id |
4175 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
1.0 mg/ml |
| Gene Full Name |
Minichromosome maintenance complex component 6 |
| Alias Symbols |
Mis5, P105MCM, MCG40308 |
| Peptide Sequence |
Synthetic peptide located within the following region: RIIEKVIHRLTHYDHVLIELTQAGLKGSTEGSESYEEDPYLVVNPNYLLE |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reference |
Yabuta,N., et al., (2003) Genes Cells 8 (5), 413-421 |
| Description of Target |
The protein encoded by the MCM6 gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of the complex by CDC2 kinase reduces the helicase activity, suggesting a role in the regulation of DNA replication. |
| Protein Interactions |
MCM10; HUWE1; SNRPB2; MCM2; NUDT2; ZBTB9; FAM161A; UBC; SUMO2; SUMO3; MCMBP; POLK; MCM4; MCM3; KPNA3; HSP90AB1; CDKN2A; ACLY; CAP1; ING5; MCM6; BAG3; TONSL; MMS22L; ASF1B; SMC1A; MCM7; CCNA1; VCAM1; ITGA4; FN1; gag-pol; GMNN; ORC6; DBF4; CDC7; PAXIP1; TP5 |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-MCM6 (ARP36650_T100) antibody |
| Blocking Peptide |
For anti-MCM6 (ARP36650_T100) antibody is Catalog # AAP36650 |
| Immunogen |
The immunogen is a synthetic peptide directed towards the C terminal region of human MCM6 |
| Uniprot ID |
Q14566 |
| Protein Name |
DNA replication licensing factor MCM6 |
| Protein Accession # |
NP_005906 |
| Purification |
Protein A purified |
| Nucleotide Accession # |
NM_005915 |
| Tested Species Reactivity |
Human |
| Gene Symbol |
MCM6 |
| Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit |
| Application |
IHC, WB |
| Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 93%; Rabbit: 100%; Rat: 93% |
| Image 1 | Human Lung
 | Human Lung |
| | Image 2 | Human HepG2
 | WB Suggested Anti-MCM6 Antibody Titration: 1.25ug/ml
Positive Control: HepG2 cell lysate |
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