| Product Number |
ARP35152_T100 |
| Product Page |
www.avivasysbio.com/accn3-antibody-n-terminal-region-arp35152-t100.html |
| Name |
ACCN3 Antibody - N-terminal region (ARP35152_T100) |
| Protein Size (# AA) |
531 amino acids |
| Molecular Weight |
58kDa |
| NCBI Gene Id |
9311 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
1.0 mg/ml |
| Gene Full Name |
Acid-sensing (proton-gated) ion channel 3 |
| Alias Symbols |
ACCN3, TNaC1, DRASIC, SLNAC1 |
| Peptide Sequence |
Synthetic peptide located within the following region: VATFLYQVAERVRYYREFHHQTALDERESHRLIFPAVTLCNINPLRRSRL |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reference |
Jones,N.G., et al., (2004) J. Neurosci. 24(48), 10974-9 |
| Description of Target |
ACCN3 encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, two hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. ACCN3 encodes a member that is an acid sensor and may play an important role in the detection of lasting pH changes. In addition, a heteromeric association between this member and ACCN1 has been observed as proton-gated channels sensitive to gadolinium. |
| Protein Interactions |
ASIC3; LIN7B; GOPC; INADL; DLG4; MAGI1; ASIC2; STOM; CSNK2A1; PRKACA; STOML1; |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-ASIC3 (ARP35152_T100) antibody |
| Blocking Peptide |
For anti-ASIC3 (ARP35152_T100) antibody is Catalog # AAP35152 (Previous Catalog # AAPP06382) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the N terminal region of human ACCN3 |
| Uniprot ID |
Q9UHC3 |
| Protein Name |
Acid-sensing ion channel 3 |
| Protein Accession # |
NP_004760 |
| Purification |
Protein A purified |
| Nucleotide Accession # |
NM_004769 |
| Tested Species Reactivity |
Human |
| Gene Symbol |
ASIC3 |
| Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit |
| Application |
IHC, WB |
| Predicted Homology Based on Immunogen Sequence |
Cow: 80%; Dog: 80%; Guinea Pig: 80%; Horse: 80%; Human: 100%; Mouse: 87%; Pig: 87%; Rabbit: 87%; Rat: 87% |
| Image 1 | Human kidney
 | Human kidney |
|
| Image 2 | Human Fetal Lung
 | Host: Rabbit
Target Name: ACCN3
Sample Tissue: Human Fetal Lung
Antibody Dilution: 1.0ug/ml |
|
| Image 3 | Hela, HepG2
 | Host: Rabbit
Target: ASIC3
Positive control (+): Hela (HL)
Negative control (-): HepG2 (HG)
Antibody concentration: 2.5ug/ml |
|
