| Product Number |
ARP33996_T100 |
| Product Page |
www.avivasysbio.com/runx1t1-antibody-middle-region-arp33996-t100.html |
| Name |
RUNX1T1 Antibody - middle region (ARP33996_T100) |
| Protein Size (# AA) |
604 amino acids |
| Molecular Weight |
68kDa |
| NCBI Gene Id |
862 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
1.0 mg/ml |
| Gene Full Name |
Runt-related transcription factor 1; translocated to, 1 (cyclin D-related) |
| Alias Symbols |
CDR, ETO, MTG8, AML1T1, ZMYND2, CBFA2T1, AML1-MTG8 |
| Peptide Sequence |
Synthetic peptide located within the following region: LHSEHPSKRPCTISPGQRYSPNNGLSYQPNGLPHPTPPPPQHYRLDDMAI |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reference |
Lausen,J., et al., (2004) J. Biol. Chem. 279 (47), 49281-49288 |
| Description of Target |
RUNX1T1 is a putative zinc finger transcription factor and oncoprotein. In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. |
| Protein Interactions |
EPS8; NECAB2; ABI3; GSE1; MID2; SPRY2; HOMER3; LPXN; ZMYM4; STX11; MEOX2; CCDC36; TRIM42; SPERT; CREB3L1; LZTS2; EFHC2; CPSF7; C19orf57; PRDM14; CBFA2T2; NCOR1; UBQLN4; ATN1; BCL6; ETS1; RUNX1; DNMT1; SPEN; RBPJ; UBE2E2; UBC; TRIM33; HDAC1; NCOR2; SIN3A; |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-RUNX1T1 (ARP33996_T100) antibody |
| Blocking Peptide |
For anti-RUNX1T1 (ARP33996_T100) antibody is Catalog # AAP33996 (Previous Catalog # AAPP05145) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the middle region of human RUNX1T1 |
| Uniprot ID |
Q06455 |
| Protein Name |
Protein CBFA2T1 |
| Sample Type Confirmation |
There is BioGPS gene expression data showing that RUNX1T1 is expressed in HepG2 RUNX1T1 is supported by BioGPS gene expression data to be expressed in 721_B |
| Protein Accession # |
NP_783554 |
| Purification |
Protein A purified |
| Nucleotide Accession # |
NM_175636 |
| Tested Species Reactivity |
Human |
| Gene Symbol |
RUNX1T1 |
| Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish |
| Application |
WB |
| Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100% |
| Image 1 | Human 721_B
 | Host: Rabbit
Target Name: WT1
Sample Type: 721_B
Antibody Dilution: 1.0ug/mlRUNX1T1 is supported by BioGPS gene expression data to be expressed in 721_B |
|
| Image 2 | Human HepG2
 | WB Suggested Anti-RUNX1T1 Antibody Titration: 1.25ug/ml
Positive Control: HepG2 cell lysateThere is BioGPS gene expression data showing that RUNX1T1 is expressed in HepG2 |
|
