| Product Number |
ARP32878_T100 |
| Product Page |
www.avivasysbio.com/ppard-antibody-middle-region-arp32878-t100.html |
| Name |
PPARD Antibody - middle region (ARP32878_T100) |
| Protein Size (# AA) |
441 amino acids |
| Molecular Weight |
49kDa |
| NCBI Gene Id |
5467 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
1.0 mg/ml |
| Gene Full Name |
Peroxisome proliferator-activated receptor delta |
| Alias Symbols |
FAAR, NUC1, NUCI, NR1C2, NUCII, PPARB |
| Peptide Sequence |
Synthetic peptide located within the following region: NPQVADLKAFSKHIYNAYLKNFNMTKKKARSILTGKASHTAPFVIHDIET |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reference |
Barish,G.D., et al., (2006) J. Clin. Invest. 116 (3), 590-597 |
| Description of Target |
PPARD is a member of the peroxisome proliferator-activated receptor (PPAR) family. PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. PPARs mediate a variety of biological processes, and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer. This protein is a potent inhibitor of ligand-induced transcription activity of PPAR delta and PPAR gamma. It may function as an integrator of transcription repression and nuclear receptor signaling. The expression of this gene is found to be elevated in colorectal cancer cells. The elevated expression can be repressed by adenomatosis polyposis coli (APC), a tumor suppressor protein related to APC/beta-catenin signaling pathway. Knockout studies in mice suggested the role of this protein in myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation. |
| Protein Interactions |
KRTAP10-3; KRTAP10-7; PLA2G4A; CTNNB1; KDM1A; PRMT3; SMAD9; HSP90AA1; TNP1; PSMG1; Nedd4; RANBP9; PRDX6; EIF3I; NCOA1; NR0B2; SHMT2; RXRG; RXRB; RXRA; PROX1; ITGB5; GLUL; RELA; HDAC1; EP300; NCOA2; SRC; SPEN; HDAC7; HDAC3; PEBP1; HDAC2; GADD45G; GADD45B; |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-PPARD (ARP32878_T100) antibody |
| Blocking Peptide |
For anti-PPARD (ARP32878_T100) antibody is Catalog # AAP32878 (Previous Catalog # AAPP03902) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the middle region of human PPARD |
| Uniprot ID |
Q03181 |
| Protein Name |
Peroxisome proliferator-activated receptor delta |
| Protein Accession # |
NP_006229 |
| Purification |
Protein A purified |
| Nucleotide Accession # |
NM_006238 |
| Tested Species Reactivity |
Human |
| Gene Symbol |
PPARD |
| Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish |
| Application |
WB |
| Predicted Homology Based on Immunogen Sequence |
Cow: 93%; Dog: 93%; Guinea Pig: 93%; Horse: 92%; Human: 100%; Mouse: 92%; Rabbit: 93%; Rat: 100%; Zebrafish: 92% |
| Image 1 | Human Jurkat
 | WB Suggested Anti-PPARD Antibody Titration: 1.25ug/ml
ELISA Titer: 1:1562500
Positive Control: Jurkat cell lysate |
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