Product Number |
ARP31932_P050 |
Product Page |
www.avivasysbio.com/csen-antibody-n-terminal-region-arp31932-p050.html |
Name |
CSEN Antibody - N-terminal region (ARP31932_P050) |
Protein Size (# AA) |
256 amino acids |
Molecular Weight |
29kDa |
NCBI Gene Id |
30818 |
Host |
Rabbit |
Clonality |
Polyclonal |
Concentration |
0.5 mg/ml |
Gene Full Name |
Kv channel interacting protein 3, calsenilin |
Alias Symbols |
CSEN, DREAM, KCHIP3 |
Peptide Sequence |
Synthetic peptide located within the following region: STVRHQPEGLDQLQAQTKFTKKELQSLYRGFKNECPTGLVDEDTFKLIYA |
Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reference |
Zaidi,N.F., et al., (2004) J. Neurochem. 89 (3), 593-601 |
Description of Target |
CSEN is a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. The protein encoded by this gene is also shown to function as a calcium-regulated transcriptional repressor, and to interact with presenilins. Mutations in the presenilin genes have been implicated in Alzheimer's disease. |
Protein Interactions |
MAVS; CD177; IGLV3-25; IL6ST; IGF1R; KCND2; CLN3; CALM2; KCNIP3; PPP3CA; GRK6; ADRBK1; UBE2I; UBC; PCBD2; TARBP2; PSEN2; CASP3; CREM; CREB1; PSEN1; CRK; |
Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
Datasheets/Manuals |
Printable datasheet for anti-KCNIP3 (ARP31932_P050) antibody |
Blocking Peptide |
For anti-KCNIP3 (ARP31932_P050) antibody is Catalog # AAP31932 (Previous Catalog # AAPP02829) |
Immunogen |
The immunogen is a synthetic peptide directed towards the N terminal region of human CSEN |
Uniprot ID |
Q9Y2W7 |
Protein Name |
Calsenilin |
Publications |
Fernandes, V. S. et al. Endogenous hydrogen sulfide has a powerful role in inhibitory neurotransmission to the pig bladder neck. J. Urol. 189, 1567-73 (2013). 23063804 |
Protein Accession # |
NP_038462 |
Purification |
Affinity Purified |
Nucleotide Accession # |
NM_013434 |
Tested Species Reactivity |
Human, Mouse |
Gene Symbol |
KCNIP3 |
Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit, Zebrafish |
Application |
IHC, WB |
Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 100%; Guinea Pig: 92%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 92% |
Image 1 | Human Jurkat
| WB Suggested Anti-CSEN Antibody Titration: 0.2-1 ug/ml Positive Control: Jurkat cell lysate |
|
Image 2 | Human kidney
| Human kidney |
|
Image 3 | Mouse Brain
| Host: Mouse Target Name: KCNIP3 Sample Tissue: Mouse Brain Antibody Dilution: 1ug/ml |
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