PPARGC1A Antibody - N-terminal region (ARP31507_P050)

• Product Number: ARP31507_P050
• Name: PPARGC1A Antibody - N-terminal region (ARP31507_P050)
• Protein Size (# AA): 798 amino acids
• Molecular Weight: 91kDa
• NCBI Gene Id: 10891
• Host: Rabbit
• Clonality: Polyclonal
• Concentration: 0.5 mg/ml
• Gene Full Name: Peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
• Alias Symbols: LEM6, PGC1, PGC1A, PGC-1v, PPARGC1, PGC-1alpha, PGC-1(alpha)
• Peptide Sequence: Synthetic peptide located within the following region: PSFDALTDGDVTTDNEASPSSMPDGTPPPQEAEEPSLLKKLLLAPANTQL
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Reference: Vimaleswaran,K.S., (er) J. Appl. Physiol. (2008) In press
• Description of Target: PPARGC1A is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity.The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
• Protein Interactions: NRIP1; SUMO1; UBE2I; UBC; SIRT1; PPARG; PRKAA1; KAT2A; EGFR; CDK6; CAPNS1; PARK7; PIAS1; SFPQ; ESRRG; RNF2; TP53; HNF4A; CREBZF; NR3C1; ESRRA; RNF34; NR1I2; ESR2; BCL6; SF1; NR5A2; MYEF2; NCOA6; IQGAP1; MYOD1; EP300; LRPPRC; THRB; MYBBP1A; MED1; NR1I3; NC
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Blocking Peptide: For anti-PPARGC1A (ARP31507_P050) antibody is Catalog # AAP31507 (Previous Catalog # AAPP02269)
• Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human PPARGC1A
• Uniprot ID: Q9UBK2
• Protein Name: Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
• Publications:

  Lee, Y. H. et al. Integrative toxicoproteomics implicates impaired mitochondrial glutathione import as an off-target effect of troglitazone. J. Proteome Res. 12, 2933-45 (2013). 23659346

• Protein Accession #: NP_037393
• Purification: Affinity Purified
• Nucleotide Accession #: NM_013261
• Tested Species Reactivity: Human, Mouse
• Gene Symbol: PPARGC1A
• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Goat, Guinea Pig, Horse, Rabbit, Zebrafish
• Application: IF, WB
• Predicted Homology Based on Immunogen Sequence: Cow: 93%; Dog: 100%; Goat: 93%; Guinea Pig: 100%; Horse: 93%; Human: 100%; Mouse: 93%; Rabbit: 93%; Rat: 100%; Zebrafish: 82%
• Image 1: Human 786-0
  
  Host: Rabbit
  Target Name: PPARGC1A
  Sample Tissue: Human 786-0
  Antibody Dilution: 1.0ug/ml
• Image 2: Mouse retina
  
  Sample Type:
  Mouse retina
  Primary Antibody Dilution:
  1:200
  Secondary Antibody:
  Donkey anti rabbit-Cy3
  Secondary Antibody Dilution:
  1:1000
  Color/Signal Descriptions:
  Red: PPARGC1A
  Gene Name:
  PPARGC1A
  Submitted by:
  Dr. Joshua Sanes