ZPK Antibody - C-terminal region (OAAB16990)

Catalog No: OAAB16990

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Western blot analysis of anti-ZPK C-term Pab (Cat. # OAAB16990) in HL-60 cell lysate (lane A) and in mouse kidney tissue lysate (lane B). ZPK (arrow) was detected using purified Pab. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.

Product Info

• Predicted Species Reactivity: Human, Mouse
• Product Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
• Clonality: Polyclonal
• Isotype: Ig
• Host: Rabbit
• Application: WB, IHC
• Additional Information: Precautions: ZPK Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
  Function: May be an activator of the JNK/SAPK pathway. Phosphorylates beta-casein, histone 1 and myelin basic protein in vitro
  Cellular Location: Cytoplasm (By similarity). Membrane; Peripheral membrane protein (By similarity)
  Tissue Location: Highly expressed in brain and kidney.
• Reconstitution and Storage: Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: This ZPK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 828-859 amino acids from the C-terminal region of human ZPK.
• Predicted Homology Based on Immunogen Sequence: Human; Mouse
• Concentration: Approximately 0.5mg/ml. Actual concentration varies with each lot.
• Application Info: WB: 1:2000
  IHC-P: 1:50~100

Target Info

• Gene Symbol: MAP3K12
• Alias Symbols: DLK, MUK, ZPK, ZPKP1, MEKK12
• NCBI Gene Id: 7786
• Protein Name: Mitogen-activated protein kinase kinase kinase 12
• Description of Target: Purified Rabbit Polyclonal Antibody (Pab)
• Uniprot ID: Q12852
• Protein Accession #: NP_001180440.1
• Molecular Weight: 93219 Da