ZMPSTE24 Antibody - N-terminal region (ARP46665_P050)

Catalog No: ARP46665_P050

WB Suggested Anti-ZMPSTE24 Antibody Titration: 0.2-1 ug/ml
Positive Control: Jurkat cell lysate

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: WB
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human ZMPSTE24
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Cow: 100%; Dog: 93%; Guinea Pig: 86%; Horse: 100%; Human: 100%; Mouse: 79%; Rabbit: 100%; Rat: 91%; Zebrafish: 90%
• Peptide Sequence: Synthetic peptide located within the following region: LYSETEGTLILLFGGIPYLWRLSGRFCGYAGFGPEYEITQSLVFLLLATL
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-ZMPSTE24 (ARP46665_P050) antibody is Catalog # AAP46665 (Previous Catalog # AAPS21603)
• Reference: Moulson,C.L., (2005) J. Invest. Dermatol. 125 (5), 913-919

Target Info

• Gene Symbol: ZMPSTE24
• Gene Full Name: Zinc metallopeptidase STE24 homolog (S. cerevisiae)
• Alias Symbols: HGPS, PRO1, FACE1, STE24, FACE-1, Ste24p
• NCBI Gene Id: 10269
• Protein Name: CAAX prenyl protease 1 homolog
• Description of Target: ZMPSTE24 is a member of the peptidase M48A family. This protein is a zinc metalloproteinase involved in the two step post-translational proteolytic cleavage of carboxy terminal residues of farnesylated prelamin A to form mature lamin A. Mutations in ZMPSTE24 gene have been associated with mandibuloacral dysplasia and restrictive dermopathy.The protein encoded by this gene is a zinc metalloprotease similar to yeast Ste24p. It is an integral membrane protein belonging to peptidase family M48 and is found in the endoplasmic reticulum and possibly in the Golgi compartment. It is thought to be involved in the proteolytic processing of farnesylated proteins.
• Uniprot ID: O75844
• Protein Accession #: NP_005848
• Nucleotide Accession #: NM_005857
• Protein Size (# AA): 475
• Molecular Weight: 55kDa
• Protein Interactions: UBC; BAG3; KIAA2013; TMEM43; MRPL40; MRPS5; SYNJ2BP; ATP6V1H; HNRNPUL1; RAB10; VDAC1; UQCRFS1P1; S100A10; RAB5C; PTPN1; NDUFB7; MGST3; HNRNPF; GALNT2; DDOST; CD55; ELAVL1; MME;