ZIP5 Antibody (OAPB01216)

Catalog No: OAPB01216

Size:100UG

Western blot analysis of ZIP5 in human spleen tissue lysate with ZIP5 antibody at 1 ug/mL.

Immunohistochemistry of ZIP5 in human spleen tissue with ZIP5 antibody at 2.5 ug/mL.

Immunofluorescence of ZIP5 in human spleen tissue with ZIP5 antibody at 20 ug/mL.

Product Info

• Predicted Species Reactivity: Human|Mouse
• Product Format: Liquid. ZIP5 Antibody is supplied in PBS containing 0.02% sodium azide.
• Clonality: Polyclonal
• Host: Rabbit
• Conjugation: Unconjugated
• Application: Enzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry-Paraffin|Western blot
• Reconstitution and Storage: ZIP5 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
• Immunogen: ZIP5 antibody was raised against a 17 amino acid synthetic peptide near the center of human ZIP5. The immunogen is located within amino acids 330 - 380 of ZIP5.
• Purification: Affinity Purified
• Concentration: 1 mg/ml
• Blocking Peptide: For anti-ZIP5 antibody is Catalog # OEPB03333
• Specificity: ZIP5 antibody is human and mouse reactive. Multiple isoforms of ZIP5 are known to exist. ZIP5 antibody is predicted to not cross-react with other ZIP family members.
• Reference: Dufner-Beattie J, Langmade SJ, Wang F, et al. Structure, function, and regulation of a subfamily of mouse zinc transporter genes. J. Biol. Chem.2003; 278:50142-50. ;
  Eide DJ. The SLC39 family of metal ion transporters. Pflugers Arch.2004; 447:796-800.;
  Taylor KM and Nicohlson RI. The LZT proteins; the LIV-1 subfamily of zinc transporters. Biochim. Biophys. Acta.2003; 1611:16-30. ;
  Wang F, Kim BE, Petris MJ, et al. The mammalian Zip5 protein is a zinc transporter that localizes to the basolateral surface of polarized cells. J. Biol. Chem.2004; 279:51433-41.

Target Info

• Gene Symbol: SLC39A5
• Gene Full Name: solute carrier family 39 member 5
• Alias Symbols: LZT-Hs7;MYP24;solute carrier family 39 (metal ion transporter), member 5;solute carrier family 39 (zinc transporter), member 5;Solute carrier family 39 member 5;zinc transporter ZIP5;ZIP5;zrt- and Irt-like protein 5.
• NCBI Gene Id: 283375
• Protein Name: Zinc transporter ZIP5|zinc transporter ZIP5 precursor [Homo sapiens]
• Description of Target: May play a role in polarized cells by carrying out serosal-to-mucosal zinc transport. Plays a role in eye development. Could regulate the BMP/TGF-beta (bone morphogenetic protein/transforming growth factor-beta) signaling pathway and modulates extracellular matrix (ECM) proteins of the sclera (PubMed:24891338). Seems to play a central role in controlling organismal zinc status (By similarity).
• Uniprot ID: Q6ZMH5
• Protein Accession #: https://www.ncbi.nlm.nih.gov/protein/NP_001128667
• Protein Size (# AA): 330-380aa