YBX1 Antibody (Phospho-Ser102) (OABF01250)

Catalog No: OABF01250

Size:100UL

Formalin-fixed and paraffin embedded human glioma tissue labeled with Anti-Phospho-YB1 (Ser102) Polyclonal Antibody, Unconjugated (OABF01250) at 1:200 followed by conjugation to the secondary antibody and DAB staining

Formalin-fixed and paraffin embedded rat kidney tissue labeled with Anti-Phospho-YB1 (Ser102) Polyclonal Antibody, Unconjugated (OABF01250) at 1:200 followed by conjugation to the secondary antibody and DAB staining

Product Info

• Predicted Species Reactivity: Bovine|Chicken|Dog|Guinea Pig|Horse|Human|Mouse|Porcine|Rabbit|Rat
• Product Format: Liquid. Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide.
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Conjugation: Unconjugated
• Application: Enzyme-linked immunosorbent assay|Immunocytochemistry|Immunofluorescence|Immunohistochemistry-Frozen|Immunohistochemistry-Paraffin|Western blot
• Additional Information: Subcellular location: Cytoplasm, Nucleus
  Modification: Phosphorylation (Ser102)
• Reconstitution and Storage: -20°C
• Immunogen: KLH conjugated synthetic phosphopeptide derived from human YB1 around the phosphorylation site of Ser102
• Purification: Protein A Purified
• Concentration: 1 ug/ul
• Application Info: WB: 1:100 - 1000
  IHC-P: : 1:100 - 500

Target Info

• Gene Symbol: YBX1
• Gene Full Name: Y-box binding protein 1
• Alias Symbols: BP-8;CBF-A;CCAAT-binding transcription factor I subunit A;CSDA2;CSDB;DBPB;DNA-binding protein B;EFI-A;enhancer factor I subunit A;major histocompatibility complex, class II, Y box-binding protein I;MDR-NF1;NSEP1;NSEP-1;nuclease-sensitive element-binding protein 1;YB1;YB-1;Y-box transcription factor;Y-box-binding protein 1.
• NCBI Gene Id: 4904
• Protein Name: Nuclease-sensitive element-binding protein 1
• Description of Target: Mediates pre-mRNA alternative splicing regulation. Binds to splice sites in pre-mRNA and regulates splice site selection. Binds and stabilizes cytoplasmic mRNA. Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors (By similarity). Regulates the transcription of numerous genes. Its transcriptional activity on the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at 'Lys-6' and 'Lys-7'. Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'), such as MDR1 and HLA class II genes. Promotes separation of DNA strands that contain mismatches or are modified by cisplatin. Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA (in vitro). May play a role in DNA repair. Component of the CRD-mediated complex that promotes MYC mRNA stability. Binds preferentially to the 5'-[CU]CUGCG-3' motif in vitro.
• Uniprot ID: P67809