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- $55: Antibody & Protein in US
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- Contact us for international orders.
Datasheets/Manuals | Printable datasheet for YAP1 Antibody (OABF01277) |
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Predicted Species Reactivity | Bovine|Dog|Horse|Human|Mouse|Porcine|Rabbit|Rat |
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Product Format | Liquid. Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. |
Clonality | Polyclonal |
Isotype | IgG |
Host | Rabbit |
Conjugation | Unconjugated |
Application | Enzyme-linked immunosorbent assay|Immunocytochemistry|Immunofluorescence|Immunohistochemistry-Frozen|Immunohistochemistry-Paraffin|Western blot |
Additional Information | Subcellular location: Cytoplasm, Nucleus |
Reconstitution and Storage | -20°C |
Immunogen | KLH conjugated synthetic peptide derived from human YAP1 |
Purification | Protein A Purified |
Concentration | 1 ug/ul |
Application Info | WB: 1:100 - 1000 IHC-P: : 1:100 - 500 |
Gene Symbol | YAP1 |
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Gene Full Name | Yes1 associated transcriptional regulator |
Alias Symbols | 65 kDa Yes-associated protein;COB1;protein yorkie homolog;transcriptional coactivator YAP1;YAP;YAP2;YAP65;Yes associated protein 1;yes-associated protein 2;yes-associated protein YAP65 homolog;YKI;yorkie homolog. |
NCBI Gene Id | 10413 |
Protein Name | Transcriptional coactivator YAP1 |
Description of Target | Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:17974916, PubMed:18280240, PubMed:18579750, PubMed:21364637). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:18158288). Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation. Acts via ARHGAP18, a Rho GTPase activating protein that suppresses F-actin polymerization (PubMed:25778702). Plays a key role to control cell proliferation in response to cell contact. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration (PubMed:18158288). The presence of TEAD transcription factors are required for it to stimulate gene expression, cell growth, anchorage-independent growth, and epithelial mesenchymal transition (EMT) induction (PubMed:18579750). |
Uniprot ID | P46937 |
- Protocol:
- Reconstitution & Storage Instructions
- Western Blotting/Immunoblotting (WB/IB) Protocol
- Immunohistochemistry (IHC) Protocol
- Immunocytochemistry (ICC) Protocol
- Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
- Blocking Peptide Competition Protocol (BPCP)
- Immunoprecipitation (IP) Protocol
- Antibody Array (AA) Protocol
- Tips Information:
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See our General FAQ page.
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What is the species homology for "YAP1 Antibody (OABF01277)"?
The tested species reactivity for this item is "". This antibody is predicted to have homology to "Bovine|Dog|Horse|Human|Mouse|Porcine|Rabbit|Rat".
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How long will it take to receive "YAP1 Antibody (OABF01277)"?
This item is available "3 to 5 business days.".
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What buffer format is "YAP1 Antibody (OABF01277)" provided in?
This item is provided in "Liquid. Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide.".
Additional format options may be available. For more information please contact info@avivasysbio.com. -
What are other names for "YAP1 Antibody (OABF01277)"?
This target may also be called "65 kDa Yes-associated protein;COB1;protein yorkie homolog;transcriptional coactivator YAP1;YAP;YAP2;YAP65;Yes associated protein 1;yes-associated protein 2;yes-associated protein YAP65 homolog;YKI;yorkie homolog." in publications.
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What is the shipping cost for "YAP1 Antibody (OABF01277)"?
The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.
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What is the guarantee for "YAP1 Antibody (OABF01277)"?
All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.
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Can I get bulk pricing for "YAP1 Antibody (OABF01277)"?
You can get bulk pricing for this item by going here.
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What is the molecular weight of the protein?
The molecular weight reported by Uniprot for this item is "".
Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics. -
What protocols are available for "YAP1 Antibody (OABF01277)"?
We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.
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What are positive controls for "YAP1"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What are negative controls for "YAP1"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What other proteins interact with "YAP1"?
This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.
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What biological processes are associated with "YAP1"?
This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.
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What cellular components are associated with "YAP1"?
This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.
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What protein functions are associated with "YAP1"?
This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.