Catalog No: OAAN00496
Price: $0.00
SKU
OAAN00496
Availability: Domestic: within 1-2 weeks delivery | International: 1-2 weeks
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Datasheets/ManualsPrintable datasheet for anti-XBP1 (OAAN00496)
Product Info
Predicted Species ReactivityHuman, Mouse, Rat
Product FormatLiquid PBS with 0.02% sodium azide, 50% glycerol (pH 7.3)
ClonalityPolyclonal
IsotypeIgG
HostRabbit
ConjugationUnconjugated
ApplicationWB, IF
::Positive Samples: 293T, NCl-H460, mouse eye, rat liver, rat eye
Cellular Location: Cytoplasm, endoplasmic reticulum membrane, endoplasmic reticulum, membrane, nucleus, peripheral membrane protein, single-pass type II membrane protein
Reconstitution and StorageStore at -20°C. Avoid repeated freeze/thaw cycles.
ImmunogenRecombinant funsion protein containing a sequence corresponding to amino acids 1-261 of human XBP1 (NP_005071.2).
PurificationAffinity purified against immunogen
Peptide SequenceMVVVAAAPNPADGTPKVLLLSGQPASAAGAPAGQALPLMVPAQRGASPEAASGGLPQARKRQRLTHLSPEEKALRRKLKNRVAAQTARDRKKARMSELEQQVVDLEEENQKLLLENQLLREKTHGLVVENQELRQRLGMDALVAEEEAEAKGNEVRPVAGSAESAALRLRAPLQQVQAQLSPLQNISPWILAVLTLQIQSLISCWAFWTTWTQSCSSNALPQSLPAWRSSQRSTQKDPVPYQPPFLCQWGRHQPSWKPLMN
Application InfoWB: 1:500~2000
IF: 1:50~200
Gene SymbolXBP1
Gene Full NameX-box binding protein 1
Alias SymbolsXBP2, TREB5, XBP-1, TREB-5
NCBI Gene Id7494
Protein NameX-box-binding protein 1
Description of TargetThis gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5.
Uniprot IDP17861
Protein Accession #NP_001073007.1
Nucleotide Accession #NM_001079539.1
Molecular Weight29 kDa
  1. What is the species homology for "XBP1 Antibody (OAAN00496)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human, Mouse, Rat".

  2. How long will it take to receive "XBP1 Antibody (OAAN00496)"?

    This item is available "Domestic: within 1-2 weeks delivery | International: 1-2 weeks".

  3. What buffer format is "XBP1 Antibody (OAAN00496)" provided in?

    This item is provided in "Liquid PBS with 0.02% sodium azide, 50% glycerol (pH 7.3)".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "XBP1 Antibody (OAAN00496)"?

    This target may also be called "XBP2, TREB5, XBP-1, TREB-5" in publications.

  5. What is the shipping cost for "XBP1 Antibody (OAAN00496)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "XBP1 Antibody (OAAN00496)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "XBP1 Antibody (OAAN00496)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "29 kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "XBP1 Antibody (OAAN00496)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "XBP1"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "XBP1"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "XBP1"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "XBP1"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "XBP1"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "XBP1"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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