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XBP1 Antibody - middle region (ARP89024_P050)

100 ul
$289.00
In Stock
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Tested Species Reactivity:
Mouse
Predicted Species Reactivity:
Mouse
Product Format:
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Clonality:
Polyclonal
Host:
Rabbit
Application:
WB
Reconstitution and Storage:
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Gene Symbol:
XBP1
Official Gene Full Name:
X-box binding protein 1
NCBI Gene Id:
22433
Protein Name:
X-box-binding protein 1
Swissprot Id:
O35426-2
Protein Accession #:
NP_001258659.1
Nucleotide Accession #:
NM_001271730.1
Alias Symbols:
TREB5, XBP-1, TREB-5, D11Ertd39e
Description of Target:
Functions as a transcription factor during endoplasmic reticulum stress by regulating the unfolded protein response (UPR). Required for cardiac myogenesis and hepatogenesis during embryonic development and the development of secretory tissues such as exocrine pancreas and salivary gland. Involved in differentiation of B lymphocytes to plasma cells and production of immunoglobulins. Modulates the cellular response to ER stress in a PIK3R-dependent manner. Binds to the cis-acting X box present in the promoter regions of major histocompatibility complex class II genes (By similarity). Involved in VEGF-induced endothelial cell (EC) proliferation and retinal blood vessel formation during embryonic development but also for angiogenesis in adult tissues under ischemic conditions. Functions also as a major regulator of the UPR in obesity-induced insulin resistance and type 2 diabetes for the management of obesity and diabetes prevention.
Protein Size (# AA):
371
Molecular Weight:
40 kDa
Purification:
Affinity purified
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express XBP1.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express XBP1.
Immunogen:
The immunogen is a synthetic peptide directed towards the middle region of mouse XBP1
Peptide Sequence:
Synthetic peptide located within the following region: PRAAGSEASGTPQARKRQRLTHLSPEEKALRRKLKNRVAAQTARDRKKAR
Concentration:
Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Blocking Peptide:
For anti-XBP1 (ARP89024_P050) antibody is Catalog # AAP89024
Datasheets/Manuals:
Printable datasheet for anti-XBP1 (ARP89024_P050) antibody

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