XBP1 Antibody - middle region (ARP89024_P050)

Catalog No: ARP89024_P050

Host: Rabbit
Target Name: XBP1
Sample Tissue: Mouse Heart lysates
Antibody Dilution: 1ug/ml

Product Info

• Tested Species Reactivity: Mouse
• Predicted Species Reactivity: Mouse
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: WB
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: The immunogen is a synthetic peptide directed towards the middle region of mouse XBP1
• Purification: Affinity purified
• Peptide Sequence: Synthetic peptide located within the following region: PRAAGSEASGTPQARKRQRLTHLSPEEKALRRKLKNRVAAQTARDRKKAR
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-XBP1 (ARP89024_P050) antibody is Catalog # AAP89024

Target Info

• Gene Symbol: XBP1
• Gene Full Name: X-box binding protein 1
• Alias Symbols: TREB, XBP-, TREB-, TREB5, XBP-1, TREB-5, D11Ertd39, D11Ertd39e
• NCBI Gene Id: 22433
• Protein Name: X-box-binding protein 1
• Description of Target: Functions as a transcription factor during endoplasmic reticulum stress by regulating the unfolded protein response (UPR). Required for cardiac myogenesis and hepatogenesis during embryonic development and the development of secretory tissues such as exocrine pancreas and salivary gland. Involved in differentiation of B lymphocytes to plasma cells and production of immunoglobulins. Modulates the cellular response to ER stress in a PIK3R-dependent manner. Binds to the cis-acting X box present in the promoter regions of major histocompatibility complex class II genes (By similarity). Involved in VEGF-induced endothelial cell (EC) proliferation and retinal blood vessel formation during embryonic development but also for angiogenesis in adult tissues under ischemic conditions. Functions also as a major regulator of the UPR in obesity-induced insulin resistance and type 2 diabetes for the management of obesity and diabetes prevention.
• Uniprot ID: O35426-2
• Protein Accession #: NP_001258659.1
• Nucleotide Accession #: NM_001271730.1
• Protein Size (# AA): 371
• Molecular Weight: 40 kDa