WTAP Recombinant Protein (OPCD00548)

Catalog No: OPCD00548

WTAP Recombinant Protein (OPCD00548) using SDS-PAGE

WTAP Recombinant Protein (OPCD00548) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Homo sapiens|Human
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Conjugation: Unconjugated
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: Met1-Asp150
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 200 ug/mL (prior to lyoph)
• Purity: > 95%
• Source: E.coli
• Tag: N-terminal His Tag

Target Info

• Gene Symbol: WTAP
• Gene Full Name: WT1 associated protein
• Alias Symbols: female-lethal(2)D homolog;hFL(2)D;Mum2;PNAS-132;pre-mRNA-splicing regulator WTAP;putative pre-mRNA splicing regulator female-lethal(2D);Wilms tumor 1 associated protein;wilms tumor 1-associating protein;Wilms' tumour 1-associating protein;WT1-associated protein.
• NCBI Gene Id: 9589
• Protein Name: Pre-mRNA-splicing regulator WTAP
• Description of Target: Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Required for accumulation of METTL3 and METTL14 to nuclear speckle (PubMed:24316715, PubMed:24407421, PubMed:24981863). Acts as a mRNA splicing regulator (PubMed:12444081). Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability (PubMed:17088532). Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes (PubMed:17095724).
• Uniprot ID: Q15007
• Protein Accession #: NP_001257460.1
• Nucleotide Accession #: NM_001270531.1
• Protein Size (# AA): Met1~Asp150
• Molecular Weight: 21kDa