Katheleen Gardiner: Dedicated to Down Syndrome Research

Down syndrome has long been regarded by many in both basic and clinical research as too complex a challenge for effective pharmacological intervention. This attitude, however, should change now that several different drugs have been shown to rescue learning and memory deficits in a major mouse -model of Down syndrome.”

– Katheleen Gardiner

(www.down-syndrome.org)

Down syndrome is a genetic condition caused by the presence of an extra Human Chromosome 21(Hsa21), more commonly known as trisomy 21. This extra chromosome causes an increase in the amount of RNA made and therefore an increase in the amount of protein expressed. It is a difficult area of research due to the breadth of genes involved as well as the lack of knowledge about each gene. In addition, research conducted on mice models show that the genes on Hsa21 are spread out over 3 chromosomes in mice, making it extremely difficult to express genes in the same manner as a human with Down syndrome.

Katheleen Gardiner is a Professor in the Department of Pediatrics at the University of Colorado Denver. She currently working on discovering novel Hsa21 proteins expressed in Down syndrome to gain a better understanding at the genetic level. She recently tested Aviva antibodies that are related to Down syndrome and found many that work well in her experiments!

These products have been independently validated on Western Blots using either human lymphoblastoid cell-lines (LCL) and/or mouse brain lysates. All lanes contain 30ug of lysates and were prepared using sonication. All antibodies were diluted 1:500 to 1:1000 and detected with an anti-rabbit alkaline-phosphatase conjugated secondary.

Take a look at Gardiner’s Western Blots now uploaded on the product pages and forum:
CAT# ARP40342: ADARB1
CAT# ARP32650: AIRE
CAT# ARP45837: CCT8
CAT# ARP45826: CHAF1B
CAT# ARP45862: DONSON
CAT# ARP57967: ERG
CAT# ARP38592: ETS2
CAT# ARP41577: FTCD
CAT# ARP41839: LSS
CAT# ARP46077: MX1
CAT# ARP31464: OLIG2
CAT# ARP40196: PRMT2
CAT# ARP40498: SYNJ1
CAT# ARP34067: PKNOX1
CAT# ARP34563: SETD4
CAT# ARP34838: HSF2BP
CAT# ARP35388: CLIC6
CAT# ARP38457: RCAN1
CAT# ARP38532: HMGN1
CAT# ARP38551: SIM2
CAT# ARP40326: U2AF1
CAT# ARP42552: C21ORF7
CAT# ARP43201: ZNF294
CAT# ARP45746: CBS
CAT# ARP45758: NDUFV3
CAT# ARP45760: PDE9A
CAT# ARP45764: SH3BGR
CAT# ARP45774: PFKL
CAT# ARP45803: COL6A1
CAT# ARP45805: COL6A2
CAT# ARP45812: RRP1
CAT# ARP45819: C21ORF2
CAT# ARP45850: RRP1B
CAT# ARP45873: C21ORF59
CAT# ARP45912: C21ORF13
CAT# ARP46611: IFNGR2
CAT# ARP57684: TMPRSS3
CAT# P100814: RUNX1

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