WNT5A Recombinant Protein (OPCD07976)

Catalog No: OPCD07976

Product Info

• Predicted Species Reactivity: Mouse|Mus musculus
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Conjugation: Unconjugated
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: Ile62-Lys380
  Subcellular Location: Secreted, extracellular matrix
  Predicted isoelectric point: 8.8
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 200 ug/mL (prior to lyoph)
• Purity: > 95%
• Source: E.coli
• Tag: N-terminal GST Tag

Target Info

• Gene Symbol: Wnt5a
• Gene Full Name: wingless-type MMTV integration site family, member 5A
• Alias Symbols: 8030457G12Rik;protein Wnt-5a;wingless-related MMTV integration site 5A;Wnt-;Wnt-5a.
• NCBI Gene Id: 22418
• Protein Name: Protein Wnt-5a
• Description of Target: Ligand for members of the frizzled family of seven transmembrane receptors (PubMed:17117926). Can activate or inhibit canonical Wnt signaling, depending on receptor context (PubMed:16602827). In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression (PubMed:16602827). Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration (PubMed:17117926). Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor. Mediates motility of melanoma cells (By similarity). Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle (PubMed:10021340). Inhibits type II collagen expression in chondrocytes (By similarity).
• Uniprot ID: p22725
• Protein Accession #: NP_001243153.1
• Nucleotide Accession #: NM_001256224.1
• Protein Size (# AA): Ile62~Lys380
• Molecular Weight: 40kDa